基因集到微小RNA：在基因列表中寻找协同微小RNA活性的特征
GeneSet2miRNA: finding the signature of cooperative miRNA activities in the gene lists.
作者信息
Antonov Alexey V, Dietmann Sabine, Wong Philip, Lutter Dominik, Mewes Hans W
机构信息
Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Institute for Bioinformatics and Systems Biology, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Germany.
出版信息
Nucleic Acids Res. 2009 Jul;37(Web Server issue):W323-8. doi: 10.1093/nar/gkp313. Epub 2009 May 6.
Abstract
GeneSet2miRNA is the first web-based tool which is able to identify whether or not a gene list has a signature of miRNA-regulatory activity. As input, GeneSet2miRNA accepts a list of genes. As output, a list of miRNA-regulatory models is provided. A miRNA-regulatory model is a group of miRNAs (single, pair, triplet or quadruplet) that is predicted to regulate a significant subset of genes from the submitted list. GeneSet2miRNA provides a user friendly dialog-driven web page submission available for several model organisms. GeneSet2miRNA is freely available at http://mips.helmholtz-muenchen.de/proj/gene2mir/.
摘要
GeneSet2miRNA是首个基于网络的工具，能够识别基因列表是否具有miRNA调控活性的特征。作为输入，GeneSet2miRNA接受一个基因列表。作为输出，会提供一个miRNA调控模型列表。一个miRNA调控模型是一组miRNA（单个、成对、三个或四个），预计可调控提交列表中相当一部分基因。GeneSet2miRNA提供了一个用户友好的对话框驱动网页提交方式，适用于多种模式生物。可通过http://mips.helmholtz-muenchen.de/proj/gene2mir/免费获取GeneSet2miRNA。
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