Fortune Brad, Yang Hongli, Strouthidis Nicholas G, Cull Grant A, Grimm Jonathan L, Downs J Crawford, Burgoyne Claude F
Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Health System, Portland, Oregon 97232, USA.
Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4719-26. doi: 10.1167/iovs.08-3289. Epub 2009 May 6.
To determine whether acutely elevated intraocular pressure (IOP) alters peripapillary retinal thickness, retinal nerve fiber layer thickness (RNFLT), or retardance.
Nine adult nonhuman primates were studied while under isoflurane anesthesia. Retinal and RNFLTs were measured by spectral domain optical coherence tomography 30 minutes after IOP was set to 10 mm Hg and 60 minutes after IOP was set to 45 mm Hg. RNFL retardance was measured by scanning laser polarimetry in 10-minute intervals for 30 minutes while IOP was 10 mm Hg, then for 60 minutes while IOP was 45 mm Hg, then for another 30 minutes after IOP was returned to 10 mm Hg.
RNFLT measured 1120 microm from the ONH center decreased from 118.1 +/- 9.3 microm at an IOP of 10 mm Hg to 116.5 +/- 8.4 microm at 45 mm Hg, or by 1.4% +/- 1.8% (P < 0.0001). There was a significant interaction between IOP and eccentricity (P = 0.0006). Within 800 microm of the ONH center, the RNFL was 4.9% +/- 3.4% thinner 60 minutes after IOP elevation to 45 mm Hg (P < 0.001), but unchanged for larger eccentricities. The same pattern was observed for retinal thickness, with 1.1% +/- 0.8% thinning overall at 45 mm Hg (P < 0.0001), and a significant effect of eccentricity (P < 0.0001) whereby the retina was 4.8% +/- 1.2% thinner (P < 0.001) within 800 microm, but unchanged beyond that. Retardance increased by a maximum of 2.2% +/- 1.1% 60 minutes after IOP was increased to 45 mm Hg (P = 0.0031).
The effects of acute IOP elevation on retinal thickness, RNFL thickness and retardance were minor, limited to the immediate ONH surround and unlikely to have meaningful clinical impact.
确定急性眼压升高是否会改变视乳头周围视网膜厚度、视网膜神经纤维层厚度（RNFLT）或延迟。
对9只成年非人灵长类动物在异氟烷麻醉下进行研究。在眼压设定为10 mmHg后30分钟以及眼压设定为45 mmHg后60分钟，通过光谱域光学相干断层扫描测量视网膜和RNFLT。在眼压为10 mmHg时，每隔10分钟用扫描激光偏振仪测量RNFL延迟30分钟，然后在眼压为45 mmHg时测量60分钟，之后在眼压恢复到10 mmHg后再测量30分钟。
从视盘中心测量的RNFLT在眼压为10 mmHg时为118.1±9.3微米，在45 mmHg时降至116.5±8.4微米，即减少了1.4%±1.8%（P<0.0001）。眼压与偏心度之间存在显著交互作用（P = 0.0006）。在视盘中心800微米范围内，眼压升高至45 mmHg 60分钟后RNFL变薄4.9%±3.4%（P<0.001），但在更大偏心度时无变化。视网膜厚度也观察到相同模式，在45 mmHg时总体变薄1.1%±0.8%（P<0.0001），偏心度有显著影响（P<0.0001），即在800微米范围内视网膜变薄4.8%±1.2%（P<0.001），但超出该范围无变化。眼压升高至45 mmHg 60分钟后延迟最多增加2.2%±1.1%（P = 0.0031）。
急性眼压升高对视网膜厚度、RNFL厚度和延迟的影响较小，仅限于视盘周围区域，不太可能产生有意义的临床影响。
