Meng Martin, Ahlborn Carolin, Bauer Matthias, Plietzsch Oliver, Soomro Shahid A, Singh Arunoday, Muller Thierry, Wenzel Wolfgang, Bräse Stefan, Richert Clemens
Institut für Organische Chemie and Center for functional Nanostructures, Universität Karlsruhe (TH), 76131 Karlsruhe, Germany.
Chembiochem. 2009 May 25;10(8):1335-9. doi: 10.1002/cbic.200900162.
Tetrahedral DNA hybrids with tetrakis(p-hydroxyphenyl)methane cores hybridize in a sequence-specific fashion at much higher temperatures than isolated linear duplexes. Dinucleotide DNA arms suffice to induce the formation of a solid at room temperature; this demonstrates the strength of multivalent binding. The graphic shows a view of a modeled assembly.
具有四（对羟基苯基）甲烷核心的四面体DNA杂合体以序列特异性方式杂交，其温度比分离的线性双链体高得多。二核苷酸DNA臂足以在室温下诱导形成固体；这证明了多价结合的强度。该图展示了一个模拟组装体的视图。
