Khan A S, Galvin T A, Lowenstine L J, Jennings M B, Gardner M B, Buckler C E
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
J Virol. 1991 Dec;65(12):7061-5. doi: 10.1128/JVI.65.12.7061-7065.1991.
We report here the results of molecular analysis of a simian immunodeficiency virus (designated SIVstm) which was isolated from a rhesus monkey inoculated with stored lymph node tissue of an Asian stump-tailed macaque. The latter monkey had died in 1977 during an epidemic of acquired immunodeficiency and lymphoma at the California Regional Primate Research Center (L. J. Lowenstine, N. W. Lerche, P. A. Marx, M. B. Gardner, and N. C. Pedersen, p. 174-176, in M. Girard and L. Valette, ed., Retroviruses of Human AIDS and Related Animal Viruses, 1988). Nucleotide sequence analysis of the gag and env regions indicates that SIVstm is an ancient member of the SIV/human immunodeficiency virus type 2 group; it is quite divergent from known SIVs isolated from African sooty mangabeys as well as from Asian macaques. Furthermore, of all SIV strains described to date, SIVstm is the most closely related to human immunodeficiency virus type 2.
我们在此报告从一只接种了亚洲短尾猕猴储存淋巴结组织的恒河猴中分离出的猿猴免疫缺陷病毒（命名为SIVstm）的分子分析结果。后一只猴子于1977年在加利福尼亚地区灵长类动物研究中心的获得性免疫缺陷和淋巴瘤疫情期间死亡（L. J. Lowenstine、N. W. Lerche、P. A. Marx、M. B. Gardner和N. C. Pedersen，第174 - 176页，载于M. Girard和L. Valette编著的《人类艾滋病和相关动物病毒的逆转录病毒》，1988年）。gag和env区域的核苷酸序列分析表明，SIVstm是SIV/人类免疫缺陷病毒2型组的一个古老成员；它与从非洲黑眉猴以及亚洲猕猴中分离出的已知SIVs有很大差异。此外，在迄今为止描述的所有SIV毒株中，SIVstm与人类免疫缺陷病毒2型关系最为密切。
