水泡性口炎病毒缺陷干扰颗粒体外合成信使核糖核酸
In vitro synthesis of messenger RNA by a defective interfering particle of vesicular stomatitis virus.
作者信息
Colonno R J, Lazzarini R A, Keene J D, Banerjee A K
出版信息
Proc Natl Acad Sci U S A. 1977 May;74(5):1884-8. doi: 10.1073/pnas.74.5.1884.
Abstract
A defective interfering particle derived from the heat-resistant strain of vesicular stomatitis virus was analyzed for the presence of virion-associated RNA polymerase (nucleosidetriphosphate:RNA nucleotidyltransferase, EC 2.7.7.6) activtiy. The RNA synthesizing capacity of the defective particles in vitro was similar to that of the wild-type virus. Characterization of the RNA produced in vitro indicated that the defective particles were able to synthesize vesicular stomatitis virus leader RNA and four virus mRNA species that sediment at 12-18 S. These RNA products were identical to the mRNAs synthesized in vitro by the wild-type virus in regard to size, polyadenylation, capping, and methylation. In contrast to the wild-type virus, the purified defective particles did not synthesize the large mRNA species sedimenting at 31 S in vitro. Possible mechanisms of homotypic and heterotypic interferences shown by this defective particle are discussed.
摘要
对源自水疱性口炎病毒耐热株的一种缺陷干扰颗粒进行了分析，以检测其是否存在病毒体相关的RNA聚合酶（核苷三磷酸：RNA核苷酸转移酶，EC 2.7.7.6）活性。缺陷颗粒在体外的RNA合成能力与野生型病毒相似。对体外产生的RNA的特性分析表明，缺陷颗粒能够合成水疱性口炎病毒前导RNA和四种沉降系数为12 - 18 S的病毒mRNA种类。这些RNA产物在大小、聚腺苷酸化、加帽和甲基化方面与野生型病毒体外合成的mRNA相同。与野生型病毒不同，纯化的缺陷颗粒在体外不合成沉降系数为31 S的大mRNA种类。讨论了这种缺陷颗粒所表现出的同型和异型干扰的可能机制。
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