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由水疱性口炎病毒缺陷干扰颗粒的3'-OH RNA末端模板化的RNA序列。

Sequence of a RNA templated by the 3'-OH RNA terminus of defective interfering particles of vesicular stomatitis virus.

作者信息

Semler B L, Perrault J, Abelson J, Holland J J

出版信息

Proc Natl Acad Sci U S A. 1978 Oct;75(10):4704-8. doi: 10.1073/pnas.75.10.4704.

DOI:10.1073/pnas.75.10.4704
PMID:216996
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC336188/
Abstract

We have sequenced the endogenous RNA polymerase product produced by disrupted purified virions of vesicular stomatitis virus defective interfering particles by using the newer one-dimensional rapid gel sequencing techniques and confirming this with a modified two-dimensional gel vectoring technique. The sequence of this 46-nucleotide RNA is: 5'(pp)pACGAAGACCACAAAACCA-GAUAAAAAAUAAAAACCACAAGAGGG(U)COH3'. We infer that this sequence is identical to the sequence at the 5' end of infectious vesicular stomatitis virus RNA and is complementary to the sequence of the 3'-OH terminus of this defective interfering particle genome RNA.

摘要

我们利用更新的一维快速凝胶测序技术，对水泡性口炎病毒缺陷干扰颗粒的纯化裂解病毒体产生的内源性RNA聚合酶产物进行了测序，并通过改良的二维凝胶载体技术进行了确认。这条46个核苷酸的RNA序列为：5'(pp)pACGAAGACCACAAAACCA-GAUAAAAAAUAAAAACCACAAGAGGG(U)COH3'。我们推断该序列与感染性水泡性口炎病毒RNA的5'端序列相同，并且与该缺陷干扰颗粒基因组RNA的3'-OH末端序列互补。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6665/336188/b42a651ee73a/pnas00669-0081-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6665/336188/5867ccf0efc5/pnas00669-0079-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6665/336188/acba043128e5/pnas00669-0079-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6665/336188/97badb5761b0/pnas00669-0079-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6665/336188/8a5edaaff66e/pnas00669-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6665/336188/67fdb82fb6c2/pnas00669-0080-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6665/336188/3b16663ce717/pnas00669-0080-c.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6665/336188/5867ccf0efc5/pnas00669-0079-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6665/336188/acba043128e5/pnas00669-0079-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6665/336188/97badb5761b0/pnas00669-0079-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6665/336188/8a5edaaff66e/pnas00669-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6665/336188/67fdb82fb6c2/pnas00669-0080-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6665/336188/3b16663ce717/pnas00669-0080-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6665/336188/d910b17231c1/pnas00669-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6665/336188/b42a651ee73a/pnas00669-0081-b.jpg

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本文引用的文献

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A two-dimensional fractionation procedure for radioactive nucleotides.一种用于放射性核苷酸的二维分级分离程序。
J Mol Biol. 1965 Sep;13(2):373-98. doi: 10.1016/s0022-2836(65)80104-8.
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Preparative two-dimensional polyacrylamide gel electrophoresis of 32 P-labeled RNA.32P 标记 RNA 的制备型二维聚丙烯酰胺凝胶电泳
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Influenza defective interfering viral RNA is formed by internal deletion of genomic RNA.流感缺陷干扰病毒RNA是由基因组RNA内部缺失形成的。
Proc Natl Acad Sci U S A. 1980 Jan;77(1):215-9. doi: 10.1073/pnas.77.1.215.
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Nucleotide sequence and thermal property of 5S rRNA from the elder aphid. Acyrthosiphon magnoliae.
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Analysis of the recombination event generating a vesicular stomatitis virus deletion defective interfering particle.产生水疱性口炎病毒缺失型缺陷干扰颗粒的重组事件分析。
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RNA polymerase-associated interactions near template promoter sequences of defective interfering particles of vesicular stomatitis virus.水疱性口炎病毒缺陷干扰颗粒模板启动子序列附近的RNA聚合酶相关相互作用。
J Virol. 1982 Jul;43(1):241-9. doi: 10.1128/JVI.43.1.241-249.1982.
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In vitro and in vivo inhibition of primary transcription of vesicular stomatitis virus by a defective interfering particle.一种缺陷干扰颗粒对水疱性口炎病毒初级转录的体外和体内抑制作用
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Intracellular vesicular stomatitis virus leader RNAs are found in nucleocapsid structures.细胞内水泡性口炎病毒前导RNA存在于核衣壳结构中。
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Persistent noncytocidal vesicular stomatitis virus infections mediated by defective T particles that suppress virion transcriptase.由抑制病毒粒子转录酶的缺陷型T颗粒介导的持续性非杀细胞性水疱性口炎病毒感染。
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RNA polymerase activity and poly(A) synthesizing activity in defective T particles of vesicular stomatitis virus.水疱性口炎病毒缺陷型T颗粒中的RNA聚合酶活性和聚腺苷酸合成活性。
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Prophylaxis and immunization in mice by use of virus-free defective T particles to protect against intracerebral infection by vesicular stomatitis virus.通过使用无病毒缺陷T颗粒对小鼠进行预防和免疫，以防止其受到水疱性口炎病毒的脑内感染。
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Absence of transcriptase activity or transcription-inhibiting ability in defective interfering particles of vesicular stomatitis virus.水疱性口炎病毒缺陷干扰颗粒中逆转录酶活性或转录抑制能力的缺失。
Virology. 1972 Oct;50(1):150-70.
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Polysomal ribonucleic acid of vesicular stomatitis virus-infected HeLa cells.水泡性口炎病毒感染的HeLa细胞的多核糖体核糖核酸
Virology. 1970 Dec;42(4):958-68. doi: 10.1016/0042-6822(70)90344-2.
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Ribonucleic acid synthesis of vesicular stomatitis virus, II. An RNA polymerase in the virion.水泡性口炎病毒的核糖核酸合成，II。病毒粒子中的一种RNA聚合酶。
Proc Natl Acad Sci U S A. 1970 Jun;66(2):572-6. doi: 10.1073/pnas.66.2.572.