Cheng Shi-Yie, Wang Shang-Kwei, Wen Zhi-Hong, Dai Chang-Feng, Duh Chang-Yih
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
J Asian Nat Prod Res. 2009 Nov;11(11):967-73. doi: 10.1080/10286020903282806.
Chemical investigations on the organic extract of the Formosan soft coral Nephthea erecta led to the isolation of two new eudesmanoids, (4R*,5S*,6Z,10R*)-8-oxo-eudesm-6-en-5alpha,11-diol (1) and (6E,10R)-4,5-dioxo-11-methoxy-eudesm-6-ene (2), together with one new tri-nor-eudesmane sesquiterpenoid, (4S*,5E,10R*)-7-oxo-tri-nor-eudesm-5-en-4beta-ol (3). The structures of metabolites 1-3 were elucidated through extensive spectroscopic analyses and by comparison with those reported in the literature. The anti-inflammatory activity using RAW 264.7 macrophages and their cytotoxicity against selected cancer cells of 1-3 were evaluated in vitro.
对台湾软珊瑚直枝软珊瑚（Nephthea erecta）有机提取物进行的化学研究，导致分离出两种新的桉烷类化合物，(4R*,5S*,6Z,10R*)-8-氧代-桉-6-烯-5α,11-二醇（1）和(6E,10R)-4,5-二氧代-11-甲氧基-桉-6-烯（2），以及一种新的三降-桉烷倍半萜类化合物，(4S*,5E,10R*)-7-氧代-三降-桉-5-烯-4β-醇（3）。通过广泛的光谱分析并与文献报道的结构进行比较，阐明了代谢产物1-3的结构。在体外评估了使用RAW 264.7巨噬细胞对1-3的抗炎活性及其对选定癌细胞的细胞毒性。
