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抑郁症的功能性神经解剖学：腹内侧前额叶皮质和背外侧前额叶皮质的不同作用。

The functional neuroanatomy of depression: distinct roles for ventromedial and dorsolateral prefrontal cortex.

作者信息

Koenigs Michael, Grafman Jordan

机构信息

Department of Psychiatry, University of Wisconsin-Madison, 6001 Research Park Blvd, Madison, WI 53719, USA.

出版信息

Behav Brain Res. 2009 Aug 12;201(2):239-43. doi: 10.1016/j.bbr.2009.03.004. Epub 2009 Mar 17.

DOI:10.1016/j.bbr.2009.03.004
PMID:19428640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2680780/
Abstract

A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms. In this review, we describe evidence from studies employing various experimental approaches in humans (functional imaging, lesion method, and brain stimulation) that converge to implicate the ventromedial and dorsolateral sectors of prefrontal cortex as critical neural substrates for depression, albeit with distinct functional contributions. The putative roles of ventromedial and dorsolateral prefrontal cortex in depression are discussed in light of the results.

摘要

抑郁症神经科学研究的一个主要目标是确定与症状发病机制相关的脑区。在这篇综述中，我们描述了来自人类研究的证据，这些研究采用了各种实验方法（功能成像、损伤法和脑刺激），这些证据都表明前额叶皮层的腹内侧和背外侧区域是抑郁症的关键神经基础，尽管它们有着不同的功能作用。根据这些结果，我们讨论了腹内侧和背外侧前额叶皮层在抑郁症中的假定作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0349/2680780/359c31eac5ff/nihms102921f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0349/2680780/62f94b92dd61/nihms102921f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0349/2680780/61929d6030cc/nihms102921f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0349/2680780/359c31eac5ff/nihms102921f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0349/2680780/62f94b92dd61/nihms102921f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0349/2680780/61929d6030cc/nihms102921f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0349/2680780/359c31eac5ff/nihms102921f3.jpg

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