Takehara Kazuaki, Chinen Omoto, Jahangir Alam, Miyoshi Yuki, Ueno Yuichi, Ueda Shuhei, Takada Yukako, Ruenphet Sakchai, Mutoh Ken-ichiro, Okamura Masashi, Nakamura Masayuki
Laboratory of Zoonoses, School of Veterinary Medicine, Kitasato University, 35-1, Higashi 23, Towada-shi, Aomori 034-8628, Japan.
Avian Dis. 2009 Mar;53(1):34-8. doi: 10.1637/8382-062008-Reg.1.
Ceramic powder prepared by sintering of chicken feces, when mixed with avian influenza viruses or an avian adenovirus, inactivated these organisms to below detection levels. When the ceramic powder was mixed with double-distilled water, the pH of the water rose to 10 but the aqueous phase did not show any antivirus activity. After 10 washings with water or five washings with 1M Tris-HCl (pH 8.0), the ceramic powder still retained antivirus activity. Antivirus activity was not affected by the presence of organic material (33% fetal calf serum). When chicks were fed food containing 5% ceramic powder, there was no difference in body weight between normal feeding and the ceramic-mixture feeding. The mode of action of the ceramic powder remains unknown, but it possibly works by adsorbing the virus. These results show that the ceramic powder has antiviral activities and is a potentially useful tool against avian influenza on poultry farms.
通过烧结鸡粪制备的陶瓷粉末，在与禽流感病毒或禽腺病毒混合时，可将这些生物体灭活至检测水平以下。当陶瓷粉末与双蒸水混合时，水的pH值升至10，但水相未显示出任何抗病毒活性。用水洗涤10次或用1M Tris-HCl（pH 8.0）洗涤5次后，陶瓷粉末仍保留抗病毒活性。抗病毒活性不受有机物质（33%胎牛血清）存在的影响。当给雏鸡喂食含有5%陶瓷粉末的食物时，正常喂食和陶瓷混合物喂食之间的体重没有差异。陶瓷粉末的作用方式尚不清楚，但它可能通过吸附病毒起作用。这些结果表明，陶瓷粉末具有抗病毒活性，是家禽养殖场对抗禽流感的一种潜在有用工具。
