Department of Otorhinolaryngology-Head and Neck Surgery, Chosun University College of Medicine, Gwangju, Korea.
Clin Exp Otorhinolaryngol. 2009 Mar;2(1):13-9. doi: 10.3342/ceo.2009.2.1.13. Epub 2009 Mar 26.
Despite the ongoing development of treatment protocols for laryngeal squamous cell carcinoma (LSCC), the patients suffering with this malady have shown only a modestly improved outcome. This poor outcome has been attributed to the lack of therapy that's individualized to the tumor's biological properties. Various studies have showed that galectin-8 is widely expressed in tumor tissues as well as in normal tissues, and the level of the galectin-8 expression may correlate with the malignancy of human squamous cell carcinoma. The purpose of this study is to evaluate the expression of galectin-8 and to investigate its correlations with the primary stage, the nodal involvement, the clinical stage and the histologic grade of squamous cell carcinoma of the larynx.
The paraffin-embedded tissue specimens from 77 patients who were diagnosed as LSCC between 1993 and 2007 were immunohistochemically stained for galectin-8.
Immunohistochemical analysis showed that a strong positive expression of galectin-8 was correlated with the T-stages, the nodal stages and the clinical stages. However, the histopathologic grades were not correlated with the galectin-8 expression in LSCC.
The expression of galectin-8 protein can be used as a prognostic factor for patients with LSCC.
尽管针对喉鳞状细胞癌（LSCC）的治疗方案不断发展，但患有这种疾病的患者的预后仅略有改善。这种不良预后归因于缺乏针对肿瘤生物学特性的个体化治疗。各种研究表明，半乳糖凝集素-8 在肿瘤组织和正常组织中广泛表达，半乳糖凝集素-8 的表达水平可能与人类鳞状细胞癌的恶性程度相关。本研究旨在评估半乳糖凝集素-8 的表达，并探讨其与喉鳞状细胞癌的原发阶段、淋巴结受累、临床分期和组织学分级的相关性。
对 1993 年至 2007 年间诊断为 LSCC 的 77 例患者的石蜡包埋组织标本进行半乳糖凝集素-8 的免疫组织化学染色。
免疫组织化学分析表明，半乳糖凝集素-8 的强阳性表达与 T 分期、淋巴结分期和临床分期相关。然而，组织病理学分级与 LSCC 中的半乳糖凝集素-8 表达无关。
半乳糖凝集素-8 蛋白的表达可作为 LSCC 患者的预后因素。
