J Otolaryngol Head Neck Surg. 2010 Feb;39(1):28-34.
Because advanced-stage squamous cell carcinoma of the larynx undergoes a generally poor hospital course, the prognostic significance of squamous cell carcinoma in the larynx was evaluated to identify those features associated with aggressive biologic behaviour according to the immunologic and histopathologic characteristics. Molecular prognostic and predictive factors have been extensively studied in different cancers over the past decades, and some of these factors were found to be useful in diagnosis, follow-up, or even treatment of some malignant tumours.
To concretize the pathogenesis of malignant tumours in the larynx and to examine the possible prognostic factors related to malignancy.
To assess the significance of galectin-3 and Pim-1 protein in laryngeal tumours and their correlation with prognostic factors, samples from 77 patients with squamous cell carcinoma of the larynx were studied immunohistochemically. We examined the correlations of galectin-3 and Pim-1 protein expression according to tumour stage, nodal status, clinical stage, and histologic differentiation to investigate the clinical significance.
Squamous cell carcinoma showed increased galectin-3 and Pim-1 expression in the more advanced clinical stage, tumour stage, and nodal status.
The pathogenetic role of galectin-3 and Pim-1 expression in laryngeal squamous cell carcinoma indicates that galectin-3 and Pim-1 might be used as a possible prognostic factor.
由于喉鳞状细胞癌晚期的预后通常较差，因此根据免疫组织化学和组织病理学特征，评估喉鳞状细胞癌的预后意义，以确定与侵袭性生物学行为相关的特征。在过去几十年中，已经广泛研究了不同癌症中的分子预后和预测因素，其中一些因素已被发现可用于某些恶性肿瘤的诊断、随访甚至治疗。
阐明喉恶性肿瘤的发病机制，并研究与恶性肿瘤相关的可能预后因素。
为了评估半乳糖凝集素-3 和 Pim-1 蛋白在喉肿瘤中的意义及其与预后因素的相关性，对 77 例喉鳞状细胞癌患者的样本进行了免疫组织化学研究。我们根据肿瘤分期、淋巴结状态、临床分期和组织学分化来检查半乳糖凝集素-3 和 Pim-1 蛋白表达的相关性，以探讨其临床意义。
喉鳞状细胞癌中半乳糖凝集素-3 和 Pim-1 的表达随着临床分期、肿瘤分期和淋巴结状态的进展而增加。
半乳糖凝集素-3 和 Pim-1 在喉鳞状细胞癌中的发病机制作用表明，半乳糖凝集素-3 和 Pim-1 可能可用作一种可能的预后因素。
