Ostrowski K, Wlodarski K, Aden D
Somatic Cell Genet. 1975 Oct;1(4):391-5. doi: 10.1007/BF01538670.
A subline of HeLa cells was shown to induce cartilage and bone formation in congenitally athymic (nude) mice when injected intramuscularly. The chondrogenesis and osteogenesis observed was similar to that found when other inducing epithelia are injected intramuscularly into cortisone-treated mice. A tumorigenic SV40 T antigen-positive human-mouse somatic cell hybrid with human chromosomes C7 and C6 did not induce cartilage or bone formation under similar conditions. The nude mouse may thus provide a system in which to investigate experimental host-cell differentiation without the complications of immunosuppression.
已证明，将HeLa细胞的一个亚系肌内注射到先天性无胸腺（裸）小鼠体内时，可诱导软骨和骨形成。观察到的软骨形成和骨形成与将其他诱导上皮细胞肌内注射到经可的松处理的小鼠体内时所发现的情况相似。在类似条件下，具有人类染色体C7和C6的致瘤性SV40 T抗原阳性人-鼠体细胞杂种未诱导软骨或骨形成。因此，裸小鼠可能提供一个系统，用于研究实验性宿主细胞分化，而不会出现免疫抑制的并发症。
