Aden D P, Putong P, Iwasaki Y
J Natl Cancer Inst. 1977 Oct;59(4):1243-9. doi: 10.1093/jnci/59.4.1243.
Somatic cell hybrids between mouse peritoneal macrophages and simian virus 40-transformed human cells injected sc into nude mice resulted in a formation of tumors with two distinct growth rates and growth patterns: 1) rapid growing, irregularly circumscribed, with necrotic foci and prominent vascular channels lined by tumor cells and 2) slow growing, small, well-circumscribed, and nonvascular. Individual tumor cells were ultrastructurally classified as undifferentiated mesenchymal cells indistinguishable within these two tumor types. Characteristics of each tumor type were retained during subsequent passages in nude mice.
将小鼠腹腔巨噬细胞与猿猴病毒40转化的人类细胞形成的体细胞杂种经皮下注射到裸鼠体内，结果形成了具有两种不同生长速率和生长模式的肿瘤：1）生长迅速，边界不规则，有坏死灶，肿瘤细胞排列形成明显的血管通道；2）生长缓慢，体积小，边界清晰，无血管。在超微结构上，单个肿瘤细胞被归类为未分化的间充质细胞，在这两种肿瘤类型中难以区分。每种肿瘤类型的特征在随后于裸鼠体内传代过程中得以保留。
