Schortgen Frédérique, Brochard Laurent
AP-HP, Groupe Hospitalier Albert Chenevier - Henri Mondor, Réanimation Médicale, F-94000 Créteil, France.
Crit Care. 2009;13(2):130. doi: 10.1186/cc7745. Epub 2009 Apr 3.
Fluid resuscitation is widely used, and many patients are therefore exposed to plasma volume expanders. Among these, colloids, particularly hydroxyethyl starches, have been shown in recent experiments and clinical studies to induce acute kidney injury. The mechanisms of colloid-induced acute kidney injury remain incompletely elucidated. The risks associated with colloid osmotic pressure elevation in vivo and the high incidence of osmotic nephrosis lesions in experimental models and clinical studies indicate that hydroxyethyl starches can no longer be considered safe.
液体复苏被广泛应用,因此许多患者会接触到血浆容量扩充剂。其中,胶体,尤其是羟乙基淀粉,在最近的实验和临床研究中已被证明可诱发急性肾损伤。胶体诱发急性肾损伤的机制仍未完全阐明。体内胶体渗透压升高相关的风险以及实验模型和临床研究中渗透性肾病病变的高发生率表明,羟乙基淀粉不能再被视为安全的。