Zabetian Azadeh, Hadaegh Farzad, Sarbakhsh Parvin, Azizi Fereidoun
Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
BMC Public Health. 2009 May 13;9:138. doi: 10.1186/1471-2458-9-138.
Although the association of weight gain and developing metabolic syndrome (MetS) has been reported in the Western and Asian populations, data on the gender-stratified effects of weight change (including weight loss) on incident MetS and its components in the Middle East Caucasians is still scarce.
A total of 1431 men and 2036 women aged > OR years with BMI > 18.5 kg/m2 were followed over 3 years. Multivariate logistic regression analysis was used to estimate the relative risk (RR) of MetS and its components (the Adult Treatment Panel III definition) associated with gender-stratified quintiles of percent weight change. Subjects with MetS at baseline were excluded for analyzing the RR of MetS.
There was 20.4% (95% CI, 19.6-21.2) age-adjusted incident MetS (18.4% male vs. 23.1% women). In men, mild weight gain (WG) predicted high waist circumference (WC) and high triglyceride; moderate WG predicted MetS (RR 2.5, 95% CI 1.4-4.3), high WC and high blood pressure (BP); large WG predicted MetS (RR 3.2, 95% CI 1.8-5.7) and its components, except for high fasting plasma glucose. In women, mild WG predicted MetS (RR 2.5, 95% CI 1.4-4.3), high WC and high BP; moderate WG predicted Mets (RR 4.6, 95% CI 2.7-8.0), high WC and high triglyceride; large WG predicted MetS (RR 6.6, 95% CI 3.8-11.3) and its components except for low HDL-cholesterol. Mild weight loss had protective effect on high WC in both genders and MetS in men (RR 0.5, 95% CI 0.26-0.97, P = 0.04).
Weight change showed different effects on MetS in men and women. In women, mild WG predicted MetS; however, mild weight loss was protective against MetS in men and high WC in both genders.
尽管在西方和亚洲人群中已报道了体重增加与代谢综合征（MetS）发生之间的关联，但关于中东白种人中体重变化（包括体重减轻）对新发MetS及其组分的性别分层影响的数据仍然匮乏。
对总共1431名年龄大于或等于某年龄且BMI>18.5kg/m²的男性和2036名女性进行了3年的随访。采用多因素逻辑回归分析来估计与性别分层的体重变化百分比五分位数相关的MetS及其组分（成人治疗小组III定义）的相对风险（RR）。为分析MetS的RR，排除了基线时患有MetS的受试者。
年龄调整后的新发MetS为20.4%（95%CI，19.6 - 21.2）（男性为18.4%，女性为23.1%）。在男性中，轻度体重增加（WG）预示着高腰围（WC）和高甘油三酯；中度WG预示着MetS（RR 2.5，95%CI 1.4 - 4.3）、高腰围和高血压（BP）；大幅度WG预示着MetS（RR 3.2，95%CI 1.8 - 5.7）及其组分，但不包括高空腹血糖。在女性中，轻度WG预示着MetS（RR 2.5，95%CI 1.4 - 4.3）、高腰围和高血压；中度WG预示着MetS（RR 4.6，95%CI 2.7 - 8.0）、高腰围和高甘油三酯；大幅度WG预示着MetS（RR 6.6，95%CI 3.8 - 11.3）及其组分，但不包括低高密度脂蛋白胆固醇。轻度体重减轻对男女的高腰围以及男性的MetS具有保护作用（RR 0.5，95%CI 0.26 - 0.97，P = 0.04）。
体重变化对男性和女性的MetS表现出不同影响。在女性中，轻度WG预示着MetS；然而，轻度体重减轻对男性的MetS以及男女的高腰围具有保护作用。
