Maleki Ali, Rashidi Negin, Aghaei Meybodi Hamidreza, Montazeri Mahdi, Montazeri Mohammad, Falsafi Farid, Ghanavati Reza, Forughi Saeid, Alyari Farshid
Department of Cardiology, Lorestan University of Medical Sciences, Khorramabad, IR Iran.
Department of Internal Medicine, Tehran University of Medical Sciences, Tehran, IR Iran.
Int Cardiovasc Res J. 2014 Dec;8(4):156-60. Epub 2014 Dec 1.
There is evidence that inflammation may be involved in pathogenesis of MetS. Inflammatory biomarkers are moving to the forefront as the potent predictors of MetS.
The present study aimed to evaluate the association between MetS and some inflammatory biomarkers.
This community-based cross-sectional study was conducted on 800 subjects aged above 35 years selected through random sampling in Borujerd (west of Iran) from 2011 to 2013. MetS was defined based on ATP III criteria and the subjects were divided into two groups (MetS and non-MetS groups). Waist circumference and Body Mass Index (BMI) were calculated. In addition, blood samples were taken and C-Reactive Protein (CRP), lipid profile, Fasting Blood Sugar (FBS), and Bleeding Time (BT) were measured. Then, the correlations between MetS and the above-mentioned variables were estimated. After all, the data were entered into the SPSS statistical software (v. 17) and analyzed using T-test, chi-square, median test, and spearman's rank correlation.
In this study, 344 subjects (43%) met the ATP III criteria. The results showed a significant difference between MetS and non-MetS groups regarding BMI, white blood cell, total cholesterol, LDL, platelet, and high-sensitivity CPR (hs-CRP) (P < 0.0001, P = 0.040, P < 0.0001, P < 0.0001, and P = 0.045, respectively). Besides, waist circumference, Triglyceride (TG), FBS, and systolic and diastolic blood pressure were significantly higher, while HDL was significantly lower in the MetS group (P < 0.0001).
The incidence rate of MetS in our survey was higher compared to the previous reports. In addition, this incidence rate was higher in females in comparison to males. The results also showed a significant correlation between inflammatory biomarkers and MetS and that the higher levels of hs-CRP were associated with higher rate of MetS.
有证据表明炎症可能参与代谢综合征（MetS）的发病机制。炎症生物标志物正成为代谢综合征的有力预测指标。
本研究旨在评估代谢综合征与某些炎症生物标志物之间的关联。
本基于社区的横断面研究于2011年至2013年在伊朗西部博鲁杰尔德通过随机抽样选取了800名35岁以上的受试者。代谢综合征根据ATP III标准定义，受试者被分为两组（代谢综合征组和非代谢综合征组）。计算腰围和体重指数（BMI）。此外，采集血样并测量C反应蛋白（CRP）、血脂谱、空腹血糖（FBS）和出血时间（BT）。然后，估计代谢综合征与上述变量之间的相关性。最后，将数据录入SPSS统计软件（v. 17），并使用t检验、卡方检验、中位数检验和斯皮尔曼等级相关性进行分析。
在本研究中，344名受试者（43%）符合ATP III标准。结果显示，在BMI、白细胞、总胆固醇、低密度脂蛋白、血小板和高敏CPR（hs-CRP）方面，代谢综合征组与非代谢综合征组之间存在显著差异（分别为P < 0.0001、P = 0.040、P < 0.0001、P < 0.0001和P = 0.045）。此外，代谢综合征组的腰围、甘油三酯（TG）、空腹血糖以及收缩压和舒张压显著更高，而高密度脂蛋白显著更低（P < 0.0001）。
我们调查中代谢综合征的发病率高于先前报告。此外，女性的发病率高于男性。结果还显示炎症生物标志物与代谢综合征之间存在显著相关性，且hs-CRP水平越高，代谢综合征的发生率越高。
