Departments of Obstetrics and Gynecology, Tokyo Women's Medical University, Tokyo 162-8666, Japan.
J Bone Miner Metab. 2009;27(6):682-8. doi: 10.1007/s00774-009-0095-1. Epub 2009 May 14.
Insufficient levels of serum 25-hydroxyvitamin D [25(OH)D] lead to low bone mineral density (BMD) by increasing serum levels of intact parathyroid hormone (PTH), and are associated with a high mortality rate. Therefore, the 25(OH)D level is used as an indicator of frailty in older persons. To obtain higher serum 25(OH)D levels, management of lifestyle habits and nutrient intake is important beginning in a person's younger years. This study evaluated the degree of association between serum 25(OH)D concentrations and lifestyle factors in young Japanese women. A cohort study was conducted from December 2003, and the survey was finished by February 2004. The subjects were 274 Japanese women aged 19-25 years old. The parameters evaluated in these subjects included: (1) serum concentrations of 25(OH)D, intact PTH, calcium, and phosphorus; (2) BMD in the lumbar spine and hip; and (3) lifestyle factors (nutrient intake, physical activity, and duration of sunlight exposure). The serum 25(OH)D level was negatively associated with the intact PTH level (Spearman; r = -0.17, P = 0.006). The BMD was significantly higher in the high 25(OH)D and low intact PTH group than the other group (P < 0.05). The serum 25(OH)D level was significantly correlated with daily intake of dietary vitamin D (r = 0.20, P = 0.001), the mean number of steps taken per day (r = 0.16, P = 0.010) and the mean time spent in sedentary activity (r = -0.14, P = 0.018) among the lifestyle factors evaluated. Multiple regression analysis showed the degree of association between lifestyle factors and serum 25(OH)D to be small (R (2) = 0.084). Daily intake of dietary vitamin D and daily walking may be useful for increasing the serum 25(OH)D level in young Japanese women.
血清 25-羟维生素 D [25(OH)D] 水平不足会通过增加完整甲状旁腺激素 (PTH) 的血清水平导致骨密度降低，并与高死亡率相关。因此，25(OH)D 水平被用作老年人虚弱的指标。为了获得更高的血清 25(OH)D 水平，从年轻时开始管理生活方式习惯和营养素摄入非常重要。本研究评估了血清 25(OH)D 浓度与年轻日本女性生活方式因素之间的关联程度。一项队列研究于 2003 年 12 月进行，并于 2004 年 2 月完成调查。研究对象为 274 名年龄在 19-25 岁的日本女性。这些受试者的参数评估包括：（1）血清 25(OH)D、完整 PTH、钙和磷浓度；（2）腰椎和髋部的骨密度；（3）生活方式因素（营养素摄入、体力活动和阳光暴露时间）。血清 25(OH)D 水平与完整 PTH 水平呈负相关（Spearman；r = -0.17，P = 0.006）。高 25(OH)D 和低完整 PTH 组的骨密度明显高于其他组（P < 0.05）。血清 25(OH)D 水平与膳食维生素 D 的每日摄入量显著相关（r = 0.20，P = 0.001），与每天行走的平均步数（r = 0.16，P = 0.010）和久坐活动的平均时间（r = -0.14，P = 0.018）相关。多元回归分析显示，生活方式因素与血清 25(OH)D 之间的关联程度较小（R 2 = 0.084）。每日膳食维生素 D 摄入和日常步行可能有助于增加年轻日本女性的血清 25(OH)D 水平。
