Amedica Corporation, Salt Lake City, Utah 84108, USA.
J Biomed Mater Res A. 2010 Mar 15;92(4):1598-605. doi: 10.1002/jbm.a.32498.
Achieving solid skeletal attachment is a requirement for the clinical success of orthopedic implants. Porous or roughened surfaces and coatings have been developed and used with mixed success to achieve attachment due to bone ingrowth. Silicon nitride is a high performance ceramic whose strength, imaging properties, and biocompatibility make it a candidate material for orthopedic implants. A porous form of silicon nitride, cancellous-structured ceramic (CSC), has been developed. CSC is a nonresorbable, partially radiolucent porous structure that can be bonded to orthopedic implants made of silicon nitride to facilitate skeletal attachment. The purpose of this study was to quantify the extent and rate of bone ingrowth into CSC in a large animal model. Cylindrical implants were placed bilaterally using staged surgeries in the medial femoral condyle of six sheep. Condyles were retrieved after 3 and 6 months in situ and prepared for examination of bone growth under SEM. Bone grew into CSC to extents and at rates similar to those reported for other titanium porous surfaces in studies involving large animals and postmortem retrievals in humans. Bone ingrowth was observed at depths of penetration greater than 3 mm in some implants after only 12 weeks in situ. Bone ingrowth into CSC is a viable method for achieving skeletal attachment.
实现坚固的骨骼附着是骨科植入物临床成功的要求。多孔或粗糙的表面和涂层已经被开发出来并被用于实现附着，这是由于骨长入。氮化硅是一种高性能陶瓷，其强度、成像性能和生物相容性使其成为骨科植入物的候选材料。一种多孔形式的氮化硅，松质结构陶瓷（CSC）已经被开发出来。CSC 是一种不可吸收的、部分半透明的多孔结构，可以与氮化硅制成的骨科植入物结合，以促进骨骼附着。本研究的目的是在大动物模型中定量评估 CSC 中骨长入的程度和速率。使用分期手术将圆柱形植入物双侧放置在 6 只羊的股骨内侧髁中。在体内 3 个月和 6 个月后取出髁，并准备在 SEM 下检查骨生长情况。在涉及大动物和人类死后取出的研究中，骨长入 CSC 的程度和速率与其他钛多孔表面相似。在体内仅 12 周后，一些植入物的穿透深度超过 3 毫米处观察到骨长入。CSC 中的骨长入是实现骨骼附着的一种可行方法。
