Zagra Antonino, Giudici Fabrizio, Minoia Leone, Corriero Andrea Saverio, Zagra Luigi
Department of Spinal Surgery, Galeazzi Orthopaedic Institute, Via Riccardo Galeazzi, 4, Milan 20161, Italy.
Eur Spine J. 2009 Jun;18 Suppl 1(Suppl 1):151-5. doi: 10.1007/s00586-009-0997-6. Epub 2009 May 15.
Grob et al. (Eur Spine J 5:281-285, 1996) illustrated a new fixation technique in inveterate cases of grade 2-3 spondylolisthesis (degenerative or spondylolytic): a fusion without reduction of the spondylolisthesis. Fixation of the segment was achieved by two cancellous bone screws inserted bilaterally through the pedicles of the lower vertebra into the body of the upper slipped vertebra. Since 1998 we have been using this technique according to the authors' indications: symptomatic spondylolisthesis with at least 25% anterior slippage and advanced disc degeneration. Afterwards this technique was used also in spondylolisthesis with low reduction of the disc height and slippage less than 25%. In every case we performed postero-lateral fusion and fixation with two AO 6.5 Ø thread 16 mm cancellous screws. From 1998 to 2002 we performed 62 fusions for spondylolisthesis with this technique: 28 males (45.16%) and 34 females (54.84%), mean age 45 years (14-72 years). The slipped vertebra was L5 in 57 cases (92%), L4 in 2 cases (3.2%), L3 in 1 case (1.6%), combined L4 and L5 in 2 cases (3.2%). In all cases there was an ontogenetic spondylolisthesis with lysis. Lumbar pain was present in 22 patients and lumbar-radicular pain was present in 40 patients. The mean preoperative VAS was 6.2 (range 5-8) for lumbar pain, and 5.5 (range 4-7) for leg pain. The fusion area was L5-S1 in 53 cases (85.5%), L3-L4 in 1 case (1.6%), L4-S1 in 8 cases (12.9%). A decompression of the spinal canal by laminectomy was performed in 33 procedures (53%). When possible a bone graft was done from the removed neural arc, and from the posterior iliac crest in the other cases. The mean blood loss was about 254 ml (100-1,000). The mean operative time was 75 min (range 60-90). The results obtained by computerized analysis at follow-up at least 5 years after surgery showed a significant improvement in preoperative symptoms. The patients were asymptomatic in 52 cases (83.9%); strained-back pain was present in 8 cases (12.9%), and there was persistent lumbar-radicular pain in 2 cases (3.2%). The mean ODI score was 2.6%, the mean VAS back pain was 1.3, the mean VAS leg pain 0.7. Some complications were observed: a nerve root compression by a screw invasion of intervertebral foramen, resolved by screw removal; an iliac artery compression by a lateral exit screw from pediculo, resolved by screw removal; a deep iliac vein phlebitis with thrombosis caused by external compression due to a wrong intraoperative position, treated by medicine. Two cases of synthesis mobilization and two cases of broken screws was detected. No cases of pseudoarthrosis and immediate or late superficial or deep infection were observed. The analysis of the long-term results of the spondylolisthesis surgical treatment with direct pediculo-body screw fixation and postero-lateral fusion gave a very satisfactory response. The technique is reliable in allowing an optimal primary stability, creating the best biomechanical conditions to obtain a solid fusion.
格罗布等人(《欧洲脊柱杂志》5:281 - 285,1996年)阐述了一种针对2 - 3级脊椎滑脱(退行性或峡部裂性)顽固性病例的新型固定技术:不复位脊椎滑脱的融合术。通过双侧经下位椎弓根插入上位滑脱椎体的两枚松质骨螺钉实现节段固定。自1998年起,我们一直按照作者的指征使用该技术:症状性脊椎滑脱,前滑脱至少25%且伴有严重椎间盘退变。之后,该技术也用于椎间盘高度降低较少且滑脱小于25%的脊椎滑脱病例。每种情况下,我们均采用两枚AO 6.5毫米直径、16毫米长的螺纹松质骨螺钉进行后外侧融合与固定。1998年至2002年,我们用此技术进行了62例脊椎滑脱融合术:男性28例(45.16%),女性34例(54.84%),平均年龄45岁(14 - 72岁)。滑脱椎体为L5的有57例(92%),L4的2例(3.2%),L3的1例(1.6%),L4和L5联合的2例(3.2%)。所有病例均为先天性脊椎滑脱伴峡部裂。22例患者有腰痛,40例患者有腰神经根性疼痛。术前腰痛的平均视觉模拟评分(VAS)为6.2(范围5 - 8),腿痛为5.5(范围4 - 7)。融合节段为L5 - S1的53例(85.5%),L3 - L4的1例(1.6%),L4 - S1的8例(12.9%)。33例手术(53%)进行了椎板切除术减压椎管。可能的情况下,取自切除的神经弓进行植骨,其他情况取自髂后嵴。平均失血量约254毫升(100 - 1000)。平均手术时间为75分钟(范围60 - 90)。术后至少5年随访的计算机化分析结果显示,术前症状有显著改善。52例患者无症状(83.9%);8例患者有背部牵扯痛(12.9%),2例患者有持续性腰神经根性疼痛(3.2%)。平均功能障碍指数(ODI)评分为2.6%,平均腰痛VAS为1.3,平均腿痛VAS为0.7。观察到一些并发症:螺钉侵入椎间孔导致神经根受压,通过取出螺钉解决;椎弓根外侧出口螺钉压迫髂动脉,通过取出螺钉解决;术中体位错误导致外部压迫引起髂总静脉血栓性深静脉炎,通过药物治疗。检测到2例内固定松动和2例螺钉断裂。未观察到假关节形成及即刻或晚期浅表或深部感染病例。对直接经椎弓根 - 椎体螺钉固定及后外侧融合的脊椎滑脱手术治疗的长期结果分析给出了非常令人满意的结果。该技术在提供最佳初始稳定性方面可靠,创造了获得坚实融合的最佳生物力学条件。