Pohl Hana R, Mumtaz Moiz M, Scinicariello Franco, Hansen Hugh
Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Division of Toxicology and Environmental Medicine, 1600 Clifton Road, F-32, Atlanta, GA 30333, USA.
Regul Toxicol Pharmacol. 2009 Aug;54(3):264-71. doi: 10.1016/j.yrtph.2009.05.003. Epub 2009 May 13.
The paper reflects on the last 15years of experience in the field of mixtures risk assessment. It summarizes results found in various documents developed by the Agency for Toxic Substances and Disease Registry (ATSDR) of the weight-of-evidence (WOE) approach applied to 380 binary combinations of chemicals. Of these evaluations, 156 assessments indicated possible additivity of effects [=], 76 indicated synergism (greater-than-additive effects [>]), and 57 indicated antagonism (less-than-additive effects [<]). However, 91 combinations lacked the minimum information needed for making any assessments and, hence, were undetermined. The paper provides examples of the rationale behind some of the WOE decisions and discusses the importance of expert judgments in risk assessment evaluations. Examples are given regarding the importance of human variability in mixtures' ability to affect human health and regarding the dose versus effect relationships.
本文回顾了混合物风险评估领域过去15年的经验。它总结了美国有毒物质和疾病登记署（ATSDR）制定的各种文件中关于证据权重（WOE）方法应用于380种二元化学物组合的结果。在这些评估中，156项评估表明可能存在效应相加[=]，76项表明存在协同作用（效应大于相加[>]），57项表明存在拮抗作用（效应小于相加[<]）。然而，91种组合缺乏进行任何评估所需的最低信息，因此无法确定。本文提供了一些WOE决策背后的基本原理示例，并讨论了专家判断在风险评估中的重要性。给出了关于人类变异性在混合物影响人类健康能力方面的重要性以及剂量与效应关系的示例。
