多种放线菌的rpsL和rsmG突变体产生抗生素过量
Antibiotic overproduction by rpsL and rsmG mutants of various actinomycetes.
作者信息
Tanaka Yukinori, Komatsu Mamoru, Okamoto Susumu, Tokuyama Shinji, Kaji Akira, Ikeda Haruo, Ochi Kozo
机构信息
National Food Research Institute, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan.
出版信息
Appl Environ Microbiol. 2009 Jul;75(14):4919-22. doi: 10.1128/AEM.00681-09. Epub 2009 May 15.
Abstract
Certain streptomycin resistance mutations (i.e., rpsL and rsmG) result in the overproduction of antibiotics in various actinomycetes. Moreover, rpsL rsmG double-mutant strains show a further increase in antibiotic production. rpsL but not rsmG mutations result in a marked enhancement of oligomycin production in Streptomyces avermitilis and erythromycin production in Saccharopolyspora erythraea, accompanied by increased transcription of a key developmental regulator gene, bldD, in the latter organism.
摘要
某些链霉素抗性突变（即rpsL和rsmG）会导致各种放线菌中抗生素的过量产生。此外，rpsL rsmG双突变菌株显示抗生素产量进一步增加。rpsL突变而非rsmG突变导致阿维链霉菌中寡霉素产量显著提高，以及糖多孢红霉菌中红霉素产量显著提高，同时在后者中一个关键发育调节基因bldD的转录增加。
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