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多种放线菌的rpsL和rsmG突变体产生抗生素过量

Antibiotic overproduction by rpsL and rsmG mutants of various actinomycetes.

作者信息

Tanaka Yukinori, Komatsu Mamoru, Okamoto Susumu, Tokuyama Shinji, Kaji Akira, Ikeda Haruo, Ochi Kozo

机构信息

National Food Research Institute, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan.

出版信息

Appl Environ Microbiol. 2009 Jul;75(14):4919-22. doi: 10.1128/AEM.00681-09. Epub 2009 May 15.

DOI:10.1128/AEM.00681-09
PMID:19447953
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2708438/
Abstract

Certain streptomycin resistance mutations (i.e., rpsL and rsmG) result in the overproduction of antibiotics in various actinomycetes. Moreover, rpsL rsmG double-mutant strains show a further increase in antibiotic production. rpsL but not rsmG mutations result in a marked enhancement of oligomycin production in Streptomyces avermitilis and erythromycin production in Saccharopolyspora erythraea, accompanied by increased transcription of a key developmental regulator gene, bldD, in the latter organism.

摘要

某些链霉素抗性突变（即rpsL和rsmG）会导致各种放线菌中抗生素的过量产生。此外，rpsL rsmG双突变菌株显示抗生素产量进一步增加。rpsL突变而非rsmG突变导致阿维链霉菌中寡霉素产量显著提高，以及糖多孢红霉菌中红霉素产量显著提高，同时在后者中一个关键发育调节基因bldD的转录增加。

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本文引用的文献

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Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12.对RNA聚合酶或核糖体蛋白S12发生突变的放线菌菌株进行抗菌研究。
Nat Biotechnol. 2009 May;27(5):462-4. doi: 10.1038/nbt.1538. Epub 2009 Apr 26.
2
Phenotypes and gene expression profiles of Saccharopolyspora erythraea rifampicin-resistant (rif) mutants affected in erythromycin production.红色糖多孢菌利福平抗性（rif）突变体在红霉素产生方面的表型和基因表达谱。
Microb Cell Fact. 2009 Mar 30;8:18. doi: 10.1186/1475-2859-8-18.
3
Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis.阿维链霉菌中阿维菌素生物合成调控基因aveR的特性分析
Appl Microbiol Biotechnol. 2009 Apr;82(6):1089-96. doi: 10.1007/s00253-008-1850-2. Epub 2009 Jan 16.
4
A novel insertion mutation in Streptomyces coelicolor ribosomal S12 protein results in paromomycin resistance and antibiotic overproduction.天蓝色链霉菌核糖体S12蛋白中的一种新型插入突变导致巴龙霉素抗性和抗生素过量产生。
Antimicrob Agents Chemother. 2009 Mar;53(3):1019-26. doi: 10.1128/AAC.00388-08. Epub 2008 Dec 22.
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Activation of dormant bacterial genes by Nonomuraea sp. strain ATCC 39727 mutant-type RNA polymerase.诺卡氏菌属菌株ATCC 39727突变型RNA聚合酶对休眠细菌基因的激活作用。
J Bacteriol. 2009 Feb;191(3):805-14. doi: 10.1128/JB.01311-08. Epub 2008 Dec 1.
6
A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea.一种关键的发育调节因子控制着糖多孢红霉菌中抗生素红霉素的合成。
Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11346-51. doi: 10.1073/pnas.0803622105. Epub 2008 Aug 6.
7
Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces.feast or famine：全局调控因子DasR将营养应激与链霉菌的抗生素生产联系起来。
EMBO Rep. 2008 Jul;9(7):670-5. doi: 10.1038/embor.2008.83. Epub 2008 May 30.
8
Dramatic activation of antibiotic production in Streptomyces coelicolor by cumulative drug resistance mutations.天蓝色链霉菌中累积的耐药性突变对抗生素生产的显著激活作用。
Appl Environ Microbiol. 2008 May;74(9):2834-40. doi: 10.1128/AEM.02800-07. Epub 2008 Feb 29.
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From microbial differentiation to ribosome engineering.从微生物分化到核糖体工程。
Biosci Biotechnol Biochem. 2007 Jun;71(6):1373-86. doi: 10.1271/bbb.70007.
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