Semba Richard D, Ferrucci Luigi, Sun Kai, Beck Justine, Dalal Mansi, Varadhan Ravi, Walston Jeremy, Guralnik Jack M, Fried Linda P
Johns Hopkins University School of Medicine, 550 N. Broadway, Suite 700, Baltimore, MD 21205, USA.
Aging Clin Exp Res. 2009 Apr;21(2):182-90. doi: 10.1007/BF03325227.
To characterize the relationship between advanced glycation end products (AGEs) and circulating receptors for AGEs (RAGE) with cardiovascular disease mortality.
The relationships between serum AGEs, total RAGE (sRAGE), and endogenous secretory RAGE (esRAGE), and mortality were characterized in 559 community-dwelling women, double dagger 65 years, in Baltimore, Maryland.
During 4.5 years of follow-up, 123 (22%) women died, of whom 54 died with cardiovascular disease. The measure of serum AGEs was carboxymethyl-lysine (CML), a dominant AGE. Serum CML predicted cardiovascular disease mortality (Hazards Ratio [HR] for highest vs lower three quartiles, 1.94, 95% Confidence Interval [CI] 1.08-3.48, p=0.026), after adjusting for age, race, body mass index, and renal insufficiency. Serum sRAGE (ng/mL) and esRAGE (ng/mL) predicted cardiovascular disease mortality (HR per 1 Standard Deviation [SD] 1.27, 95% CI 0.98-1.65, p=0.07; HR 1.28, 95% CI 1.02-1.63, p=0.03), after adjusting for the same covariates. Among non-diabetic women, serum CML, sRAGE, and esRAGE, respectively, predicted cardiovascular disease mortality (HR for highest vs lower three quartiles, 2.29, 95% CI 1.21-4.34, p=0.01; HR per 1 SD, 1.24, 95% CI 0.92-1.65, p=0.16; HR per 1 SD 1.45, 95% CI 1.08-1.93, p=0.01), after adjusting for the same covariates.
High circulating AGEs and RAGE predict cardiovascular disease mortality among older community-dwelling women. AGEs are a potential target for interventions, as serum AGEs can be lowered by change in dietary pattern and pharmacological treatment.
明确晚期糖基化终产物（AGEs）及循环中的AGE受体（RAGE）与心血管疾病死亡率之间的关系。
在马里兰州巴尔的摩市对559名年龄≥65岁的社区居住女性进行研究，分析血清AGEs、总RAGE（sRAGE）和内源性分泌型RAGE（esRAGE）与死亡率之间的关系。
在4.5年的随访期内，123名（22%）女性死亡，其中54例死于心血管疾病。血清AGEs的检测指标为羧甲基赖氨酸（CML），这是一种主要的AGE。在调整年龄、种族、体重指数和肾功能不全因素后，血清CML可预测心血管疾病死亡率（最高四分位数与较低三个四分位数相比，风险比[HR]为1.94，95%置信区间[CI]为1.08 - 3.48，p = 0.026）。在调整相同协变量后，血清sRAGE（ng/mL）和esRAGE（ng/mL）也可预测心血管疾病死亡率（每1标准差[SD]的HR为1.27，95%CI为0.98 - 1.65，p = 0.07；HR为1.28，95%CI为1.02 - 1.63，p = 0.03）。在非糖尿病女性中，调整相同协变量后，血清CML、sRAGE和esRAGE分别可预测心血管疾病死亡率（最高四分位数与较低三个四分位数相比，HR为2.29，95%CI为1.21 - 4.34，p = 0.01；每1 SD的HR为1.24，95%CI为0.92 - 1.65，p = 0.16；每1 SD的HR为1.45，95%CI为1.08 - 1.93，p = 0.01）。
循环中高水平的AGEs和RAGE可预测老年社区居住女性的心血管疾病死亡率。AGEs是潜在的干预靶点，因为血清AGEs可通过改变饮食模式和药物治疗降低。
