Institute of Physical Culture, University of Szczecin, Szczecin, Poland.
Int J Sports Med. 2009 Aug;30(8):624-7. doi: 10.1055/s-0029-1202825. Epub 2009 May 19.
Angiotensin converting enzyme gene (ACE) is the most frequent investigated gene in the context of genetic conditioning of sports-predispositions. Product of this gene is a key-element in the renin-angiotensin system responsible for the regulation of blood pressure. In this study DNA polymorphism in the ACE gene was studied in Polish rowers in order to examine the hypothesis that ACE genotype is associated with athletes performance. Fifty-five male Polish rowers including Olympic and World champions were recruited for this study. Control samples were prepared from 115 unrelated volunteers. PCR amplification of the insertion (I) or deletion (D) fragment of ACE gene was performed. Genotype distribution and allele frequencies were determined by genotype and gene counting. Significance was assessed by chi2 analysis. ACE genotype distributions amongst subjects and controls were in Hardy-Weinberg equilibrium. Compared with controls, the frequency of I allele differ significantly from that found in rower's group: 56.3% vs. 44.3%, (P=0.038) and ACE genotype frequency amongst the whole athletes group (30.9% II, 50.9% ID, 18.2% DD) was also different from expected values (control group 19.1% II, 50.4% ID, 30.4% DD; P=0.039). This data confirm a positive association of the I allele of ACE gene with endurance performance.
血管紧张素转换酶基因（ACE）是研究与运动倾向性遗传相关的最常见基因。该基因的产物是肾素-血管紧张素系统的关键元素，负责调节血压。在这项研究中，研究了波兰赛艇运动员中 ACE 基因的 DNA 多态性，以检验 ACE 基因型与运动员表现相关的假设。 这项研究招募了 55 名包括奥运冠军和世界冠军在内的波兰男性赛艇运动员作为研究对象。对照组由 115 名无关志愿者组成。 对 ACE 基因的插入（I）或缺失（D）片段进行 PCR 扩增。通过基因计数确定基因型分布和等位基因频率。通过卡方分析评估显著性。研究对象和对照组的 ACE 基因型分布均符合哈迪-温伯格平衡。与对照组相比，I 等位基因在运动员组中的频率明显不同：56.3%对 44.3%，（P=0.038），整个运动员组的 ACE 基因型频率（30.9% II，50.9% ID，18.2% DD）也与预期值不同（对照组为 19.1% II，50.4% ID，30.4% DD；P=0.039）。这些数据证实 ACE 基因的 I 等位基因与耐力表现呈正相关。
