Shati Ali A, Elsaid Fahmy G
Biological Science Department, Faculty of Science, King Khalid University, Abha, Saudi Arabia.
Food Chem Toxicol. 2009 Aug;47(8):1945-9. doi: 10.1016/j.fct.2009.05.007. Epub 2009 May 18.
Alcohol abuse has many harmful effects on human body. This study aimed to investigate the role of water extracts of thyme (Thymus vulgaris) and ginger (Zingiber officinale Roscoe) as natural product extracts to detoxify the injuries of alcohol abuse on liver and brain of mice.
Alcohol at a dose of 1.25 ml/50 ml water was orally administered at the first day of treatment with continuously increase of 1.25 ml per day to the end of experiment (14 days, 0.1 ml/45 g /d). Mice also were orally administered with alcohol and water extracts of thyme and ginger in concentration of 500 mg /kg body weight for 2 weeks.
The results showed very highly significant increase in nitric oxide and malondialdehyde level in liver and brain and a very highly significant decrease in the total antioxidant capacity and glutathione peroxidase activity in alcoholic group. In addition, the liver function enzymes such as L-gamma-glutamyl transpeptidase and butyryl cholinesterase activities showed very highly significant increase in alcoholic group. In contrast, the water extracts of thyme and ginger showed significant amelioration on these changes both in liver and brain tissues.
The water extracts of thyme and ginger has detoxifying and antioxidant effects. Therefore, it is recommended to use them to avoid alcohol toxicity.
酒精滥用对人体有许多有害影响。本研究旨在探讨百里香（百里香属）和生姜（姜科姜属）水提取物作为天然产物提取物对酒精滥用所致小鼠肝脏和脑损伤的解毒作用。
在治疗第一天口服给予剂量为1.25 ml/50 ml水的酒精，每天持续增加1.25 ml直至实验结束（14天，0.1 ml/45 g/天）。小鼠还口服给予浓度为500 mg/kg体重的酒精以及百里香和生姜水提取物，持续2周。
结果显示，酒精组肝脏和脑中一氧化氮和丙二醛水平非常显著升高，总抗氧化能力和谷胱甘肽过氧化物酶活性非常显著降低。此外，酒精组中肝功能酶如L-γ-谷氨酰转肽酶和丁酰胆碱酯酶活性非常显著升高。相比之下，百里香和生姜水提取物对肝脏和脑组织中的这些变化均有显著改善作用。
百里香和生姜水提取物具有解毒和抗氧化作用。因此，建议使用它们来避免酒精毒性。
