Degenaar Patrick, Grossman Nir, Memon Muhammad Ali, Burrone Juan, Dawson Martin, Drakakis Emmanuel, Neil Mark, Nikolic Konstantin
Institute of Biomedical Engineering, Imperial College, London, UK.
J Neural Eng. 2009 Jun;6(3):035007. doi: 10.1088/1741-2560/6/3/035007. Epub 2009 May 20.
The recent discovery that neurons can be photostimulated via genetic incorporation of artificial opsins is creating a revolution in the field of neural stimulation. In this paper we show its potential in the field of retinal prosthesis. We show that we need typically 100 mW cm(-2) in instantaneous light intensity on the neuron in order to stimulate action potentials. We also show how this can be reduced down to safe levels in order to negate thermal and photochromic damage to the eye. We also describe a gallium nitride LED light source which is also able to generate patterns of the required intensity in order to transfer reliable images.
最近发现通过人工视蛋白的基因整合可对神经元进行光刺激，这正在神经刺激领域引发一场革命。在本文中，我们展示了其在视网膜假体领域的潜力。我们表明，为了刺激动作电位，通常需要在神经元上施加100 mW cm(-2)的瞬时光强度。我们还展示了如何将其降低到安全水平，以消除对眼睛的热损伤和光致变色损伤。我们还描述了一种氮化镓发光二极管光源，它也能够产生所需强度的图案以传输可靠图像。
