胰腺浆液性囊腺癌：病例报告及文献复习。
Pancreatic serous cystadenocarcinoma: a case report and review of the literature.
机构信息
Department of Surgery, David Geffen School of Medicine at UCLA, Box 956904, 72-170 CHS, Los Angeles, CA 90095-6904, USA.
出版信息
J Gastrointest Surg. 2009 Oct;13(10):1864-8. doi: 10.1007/s11605-009-0926-3. Epub 2009 May 21.
BACKGROUND
Serous cystic neoplasms of the pancreas are benign lesions with little chance for malignant degeneration. We report a case of malignant serous cystadenocarcinoma of the pancreas and review the literature.
METHODS
Structured review of the literature was performed using PubMed and MEDLINE searches, and cases of serous cystadenocarcinoma of the pancreas were compiled.
RESULTS
A 70-year-old man diagnosed with a serous cystadenoma was managed expectantly until he became symptomatic, and studies revealed an increase in the size of the lesion as well as duodenal invasion. The patient underwent a pancreaticoduodenectomy, and histopathological examination revealed a locally invasive cystadenocarcinoma without metastatic disease. Seven years later, the patient remains disease-free. Review of the literature identified 25 cases of serous cystadenocarcinoma published to date. The mean age at diagnosis is 68 +/- 2 years (range, 52 to 81), and women are affected more commonly (2:1).
CONCLUSIONS
We conclude that there is a small but finite risk of malignancy for serous cystic neoplasms of the pancreas. The clinician should bear this in mind when faced with decisions regarding patient management. Prognosis is excellent with multiple reports of long-term survival even in the face of metastatic disease.
背景
胰腺浆液性囊性肿瘤是良性病变，恶性转化的机会很小。我们报告一例胰腺恶性浆液性囊腺癌病例，并复习文献。
方法
使用 PubMed 和 MEDLINE 搜索进行文献的系统回顾，并对胰腺浆液性囊腺癌病例进行了汇编。
结果
一名 70 岁男性被诊断为浆液性囊腺瘤，接受了期待治疗，直到出现症状，研究显示病变大小增加并侵犯十二指肠。患者接受了胰十二指肠切除术，组织病理学检查显示局部侵袭性囊腺癌无转移疾病。7 年后，患者仍无疾病。对文献的回顾确定了迄今为止已发表的 25 例浆液性囊腺癌病例。诊断时的平均年龄为 68 +/- 2 岁（范围为 52 至 81），女性更常见（2:1）。
结论
我们得出结论，胰腺浆液性囊性肿瘤存在但风险有限的恶性转化可能。临床医生在面临患者管理决策时应牢记这一点。即使存在转移性疾病，预后也很好，有多项长期生存的报道。
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