Kaiser P, Youssouf M S, Tasduq S A, Singh S, Sharma S C, Singh G D, Gupta V K, Gupta B D, Johri R K
Division of Pharmacology and Natural Products Chemistry, Indian Institute of Integrative Medicine, Jammu-Tawi, India.
J Med Food. 2009 Apr;12(2):374-82. doi: 10.1089/jmf.2007.0642.
Allium cepa (Family Liliaceae) is a reputed Indian medicinal herb that is prescribed as an effective remedy for several ailments in the Ayurvedic system of medicine. The aim of this study was to evaluate its efficacy against various events responsible for Type I allergic reactions. A herbal fraction (ALC-02) from A. cepa (bulb) inhibited histamine release and attenuated intracellular calcium levels in Compound 48/80-induced rat peritoneal mast cells. It also prevented Compound 48/80-mediated systemic anaphylaxis while lowering histamine levels in plasma. ALC-02 suppressed carrageenan-induced rat paw edema. It inhibited eosinophil peroxidase activity and protein content in bronchoalveolar lavage fluid (BALF) of ovalbumin-challenged mice. In this experiment ALC-02 also caused a substantial reduction in lipid peroxidation in BALF/lung tissue and augmented superoxide dismutase activity in lung tissue. ALC-02 suppressed erythrocytic lysis caused by Triton X-100. A significant quenching of 1,1-diphenyl-2-picrylhydrazyl radical by ALC-02 was observed. The results have shown a promising anti-allergic profile of ALC-02 that could be attributed to its potential antihistaminic, anti-inflammatory, and antioxidant activities.
洋葱（百合科）是一种著名的印度草药，在阿育吠陀医学体系中，它被用作治疗多种疾病的有效药物。本研究的目的是评估其对引发I型过敏反应的各种事件的疗效。从洋葱（鳞茎）中提取的一种草药成分（ALC - 02）可抑制组胺释放，并降低化合物48/80诱导的大鼠腹腔肥大细胞内的钙水平。它还可预防化合物48/80介导的全身过敏反应，同时降低血浆中的组胺水平。ALC - 02可抑制角叉菜胶诱导的大鼠爪肿胀。它可抑制卵清蛋白激发的小鼠支气管肺泡灌洗液（BALF）中的嗜酸性粒细胞过氧化物酶活性和蛋白质含量。在本实验中，ALC - 02还可显著降低BALF/肺组织中的脂质过氧化，并增强肺组织中的超氧化物歧化酶活性。ALC - 02可抑制由 Triton X - 100引起的红细胞溶解。观察到ALC - 02对1,1 - 二苯基 - 2 - 苦基肼自由基有显著的淬灭作用。结果表明ALC - 02具有良好的抗过敏特性，这可能归因于其潜在的抗组胺、抗炎和抗氧化活性。
