Galavi Amin, Hosseinzadeh Hossein, Razavi Bibi Marjan
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Basic Med Sci. 2021 Jan;24(1):3-16. doi: 10.22038/ijbms.2020.46956.10843.
Metabolic syndrome as a clustering disorder includes excess abdominal fat distribution, abnormal insulin and glucose metabolism, disturbed blood lipids, pro-inflammatory state, and hypertension. Regarding to the adverse effects of synthetic medicines, the identification of appropriate healthcare approaches, such as herbal medicines, with fewer side effects is more favorable. L. (onion) is a culinary and medicinal herb belonging to the family of . Flavonoids such as quercetin and kaempferol, alk(en)yl cysteine sulfoxides including S-methyl cysteine sulfoxide and S-propyl cysteine sulfoxide, cycloalliin, thiosulfinates, and sulfides are main compounds existing in the plant. and its pharmacologically active constituents display broad-spectrum activities including anti-oxidant, anti-inflammatory, lipid-modifying, anti-obesity, antihypertensive, and antidiabetic effects. Our objective in this review was to find out the role of and its bioactive phytochemicals as cardiovascular protective agents in different metabolic syndrome risk factors, including hyperlipidemia, high blood glucose, obesity, and hypertension.
代谢综合征作为一种聚类性疾病，包括腹部脂肪分布过多、胰岛素和葡萄糖代谢异常、血脂紊乱、促炎状态和高血压。鉴于合成药物的不良反应，确定副作用较少的合适医疗方法（如草药）更为可取。葱属植物（洋葱）是一种属于葱科的烹饪和药用草本植物。黄酮类化合物如槲皮素和山奈酚、烯基半胱氨酸亚砜（包括S-甲基半胱氨酸亚砜和S-丙基半胱氨酸亚砜）、环蒜氨酸、硫代亚磺酸盐和硫化物是该植物中存在的主要化合物。葱属植物及其药理活性成分具有广泛的活性，包括抗氧化、抗炎、脂质调节、抗肥胖、抗高血压和抗糖尿病作用。我们本次综述的目的是探究葱属植物及其生物活性植物化学物质作为心血管保护剂在不同代谢综合征风险因素（包括高脂血症、高血糖、肥胖和高血压）中的作用。
