Singh G D, Kaiser P, Youssouf M S, Singh S, Khajuria A, Koul A, Bani S, Kapahi B K, Satti N K, Suri K A, Johri R K
Division of Pharmacology and Natural Products Chemistry, Regional Research Laboratory, Jammu-Tawi 180 001, India.
Phytother Res. 2006 Apr;20(4):316-21. doi: 10.1002/ptr.1844.
A 95% ethanol extract from whole aerial parts of Euphorbia hirta (EH A001) showed antihistaminic, antiinflammatory and immunosuppressive properties in various animal models. EH A001 inhibited rat peritoneal mast cell degranulation triggered by compound 48/80. It significantly inhibited dextran-induced rat paw edema. EH A001 prevented eosinophil accumulation and eosinophil peroxidase activity and reduced the protein content in bronchoalveolar lavage fluid (BALF) in a 'mild' model of asthma. Moreover, the CD4/CD8 ratio in peripheral blood was suppressed. EH A001 attenuated the release of interleukin-4 (IL-4) and augmented interferon-gamma (IFN-gamma) in ovalbumin-sensitized mouse splenocytes. The results were compared with the effects of known compounds, ketotifen, cetirizine and cyclophosphamide. These findings demonstrated that Euphorbia hirta possessed significant activity to prevent early and late phase allergic reactions.
大戟全草的95%乙醇提取物（EH A001）在多种动物模型中表现出抗组胺、抗炎和免疫抑制特性。EH A001抑制了由化合物48/80引发的大鼠腹腔肥大细胞脱颗粒。它显著抑制了右旋糖酐诱导的大鼠足爪肿胀。在“轻度”哮喘模型中，EH A001可防止嗜酸性粒细胞积聚和嗜酸性粒细胞过氧化物酶活性，并降低支气管肺泡灌洗液（BALF）中的蛋白质含量。此外，外周血中的CD4/CD8比值受到抑制。EH A001可减轻卵清蛋白致敏小鼠脾细胞中白细胞介素-4（IL-4）的释放，并增强干扰素-γ（IFN-γ）的释放。将结果与已知化合物酮替芬、西替利嗪和环磷酰胺的作用进行了比较。这些发现表明，大戟具有预防早期和晚期过敏反应的显著活性。
