一种源自海洋鱼类的毛壳菌属物种所产生的毛壳麦角菌素G和H的绝对立体结构。

Absolute stereostructures of chaetomugilins G and H produced by a marine-fish-derived Chaetomium species.

作者信息

Yamada Takeshi, Yasuhide Muroga, Shigeta Hirohumi, Numata Atsushi, Tanaka Reiko

机构信息

Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, Nasahara 4-20-1, Takatsuki, Osaka, Japan.

出版信息

J Antibiot (Tokyo). 2009 Jul;62(7):353-7. doi: 10.1038/ja.2009.39. Epub 2009 May 22.

DOI:10.1038/ja.2009.39

PMID:19461670

Abstract

Chaetomugilins G and H were isolated from a strain of Chaetomium globosum that was originally isolated from the marine fish, Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, and chemical transformation. In addition, the absolute configuration of chaetoviridin C was established by derivatization from chaetomugilin A. These compounds exhibited a growth inhibitory activity against cultured P388, HL-60, L1210 and KB cells.

摘要

Chaetomugilins G和H是从最初从海鱼鲻鱼分离得到的一株球毛壳菌中分离出来的，它们的绝对立体结构是基于包括一维和二维核磁共振技术在内的光谱分析以及化学转化来阐明的。此外，chaetoviridin C的绝对构型是通过从chaetomugilin A衍生而来确定的。这些化合物对培养的P388、HL-60、L1210和KB细胞表现出生长抑制活性。