College of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, P.R. China.
J Microbiol Biotechnol. 2022 May 28;32(5):541-550. doi: 10.4014/jmb.2201.01007.
Filamentous marine fungi have proven to be a plentiful source of new natural products. , a widely distributed fungal genus in the marine environment, has gained much interest within the scientific community. In the last 20 years, many potential secondary metabolites have been detected from marine-derived . In this review, we attempt to provide a comprehensive summary of the natural products produced by marine-derived species. A total of 122 secondary metabolites that were described from 2001 to 2021 are covered. The structural diversity of the compounds, along with details of the sources and relevant biological properties are also provided, while the relationships between structures and their bioactivities are discussed. It is our expectation that this review will be of benefit to drug development and innovation.
丝状海洋真菌已被证明是新型天然产物的丰富来源。在海洋环境中广泛分布的真菌属 ，在科学界引起了广泛关注。在过去的 20 年中，已经从海洋来源的 中检测到许多潜在的次级代谢产物。在本文综述中，我们试图对海洋来源的 物种产生的天然产物进行全面总结。共综述了 2001 年至 2021 年期间描述的 122 种次生代谢产物。提供了化合物的结构多样性，以及来源和相关生物特性的详细信息，同时还讨论了结构与生物活性之间的关系。我们希望本综述将有助于药物开发和创新。
