Cytoglobosins A-G，来源于海洋来源的内生真菌 Chaetomium globosum QEN-14 的细胞松弛素。

Cytoglobosins A-G, cytochalasans from a marine-derived endophytic fungus, Chaetomium globosum QEN-14.

机构信息

Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, People's Republic of China.

出版信息

J Nat Prod. 2010 Apr 23;73(4):729-33. doi: 10.1021/np900569t.

DOI:10.1021/np900569t

PMID:20225834

Abstract

Cytoglobosins A-G (1-7), seven new cytochalasan derivatives, along with two structurally related known compounds, isochaetoglobosin D (8) and chaetoglobosin F(ex) (9), were isolated and identified from the cultures of Chaetomium globosum QEN-14, an endophytic fungus derived from the marine green alga Ulva pertusa. The structures of the new natural products as well as their relative configurations were elucidated on the basis of 1D and 2D NMR spectra (COSY, HSQC, HMBC, and NOESY) and HRESIMS data. Cytoglobosins C and D (3 and 4) displayed cytotoxic activity against the A-549 tumor cell line.

摘要

细胞球菌素 A-G（1-7），七种新的细胞松弛素衍生物，以及两种结构相关的已知化合物，异沙托球菌素 D（8）和沙托球菌素 F（ex）（9），从海洋绿藻石莼内生真菌 Chaetomium globosum QEN-14 的培养物中分离鉴定得到。根据 1D 和 2D NMR 谱（COSY、HSQC、HMBC 和 NOESY）和 HRESIMS 数据，阐明了新天然产物的结构及其相对构型。细胞球菌素 C 和 D（3 和 4）对 A-549 肿瘤细胞系表现出细胞毒性活性。