海洋真菌中的卤代化合物综述。

Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Key Laboratory of Guangxi Colleges and Universities for Food Safety and Pharmaceutical Analytical Chemistry, School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Nanning 530006, China.

Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i, Hilo, HI 96720, USA.

Molecules. 2021 Jan 16;26(2):458. doi: 10.3390/molecules26020458.

Marine fungi produce many halogenated metabolites with a variety of structures, from acyclic entities with a simple linear chain to multifaceted polycyclic molecules. Over the past few decades, their pharmaceutical and medical application have been explored and still the door is kept open due to the need of new drugs from relatively underexplored sources. Biological properties of halogenated compounds such as anticancer, antiviral, antibacterial, anti-inflammatory, antifungal, antifouling, and insecticidal activity have been investigated. This review describes the chemical structures and biological activities of 217 halogenated compounds derived mainly from and marine fungal strains reported from 1994 to 2019.

海洋真菌产生许多具有各种结构的卤代代谢物，从具有简单线性链的无环实体到多方面的多环分子。在过去的几十年中，人们一直在探索它们在医药方面的应用，由于需要从相对未充分开发的来源中获得新药，因此这扇大门仍然敞开着。卤代化合物的生物特性，如抗癌、抗病毒、抗菌、抗炎、抗真菌、防污和杀虫活性，已经得到了研究。本文综述了 1994 年至 2019 年期间主要从和海洋真菌菌株中分离得到的 217 种卤代化合物的化学结构和生物活性。