Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Japan.
Prev Med. 2009 Apr;48(4):351-6. doi: 10.1016/j.ypmed.2009.01.013. Epub 2009 Feb 7.
Although a 5%-10% loss in the baseline weight has been associated with improvement in obesity-related disorders, only a few studies have explored the factors to alleviate metabolic syndrome (MS). This study aimed to determine the factors that alter MS components in overweight Japanese women.
Between 1999 and 2006, 323 Japanese women aged 24-67 with body mass indices of 25-40 kg/m(2) and the presence of at least 1 component of MS were recruited from Ibaraki and Chiba. The participants were enrolled in a 3-month weight-loss program with a low-calorie diet with or without exercise. The factors to alleviate MS components were explored using classification and regression tree (CART) analyses.
Of the 323 participants, 309 completed the weight-loss program and were included in the analyses. The CART analyses revealed that a weight reduction of 8.1% in baseline body weight was sufficient to improve at least 1 component of MS. Similarly, classification trees were generated for improvement in abdominal obesity (essential factor: > or =13.0% weight loss), hypertension (essential factor: baseline age, < or =41.5 years), and hyperglycemia (essential factor: > or =13.2% weight loss).
These results suggest that moderate weight loss of 8%-13% contributes to improving the MS components in overweight Japanese women.
尽管基线体重减轻 5%-10%与肥胖相关疾病的改善相关，但仅有少数研究探讨了减轻代谢综合征（MS）的因素。本研究旨在确定改变超重日本女性 MS 成分的因素。
1999 年至 2006 年间，从茨城县和千叶县招募了 323 名年龄在 24-67 岁之间、BMI 为 25-40 kg/m(2)且至少存在 1 项 MS 成分的日本女性。参与者参加了为期 3 个月的低热量饮食减肥计划，其中包括或不包括运动。使用分类和回归树（CART）分析探讨缓解 MS 成分的因素。
在 323 名参与者中，有 309 名完成了减肥计划并纳入了分析。CART 分析显示，基线体重减轻 8.1%足以改善至少 1 项 MS 成分。同样，为改善腹部肥胖（必要因素：体重减轻>或=13.0%）、高血压（必要因素：基线年龄，<或=41.5 岁）和高血糖（必要因素：体重减轻>或=13.2%）生成了分类树。
这些结果表明，适度减轻 8%-13%的体重有助于改善超重日本女性的 MS 成分。
