Atweh S F, Kuhar M J
Brain Res. 1977 Jun 24;129(1):1-12. doi: 10.1016/0006-8993(77)90965-9.
The distribution of opiate receptors, determined by the autoradiographic localization of stereospecific [3H]diprenorphine binding sites, was studied in the brain stem. Areas showing very dense or dense localizations of receptors included the parabrachial nuclei, the superior colliculus, the ventral median raphe nucleus, components of the accessory optic system, portions of the habenulo-interpeduncular complex, the pretectal nuclei and the ventral lateral geniculate, the infundibulum and the medial thalamus. Moderate grain densities were found in broad areas of the upper medulla, midbrain and diencephalon. The significance of these findings are discussed in terms of pain mechanisms, association of some receptors with small diameter axons, pupillary reflexes, hormonal control, and effects of opiates on neurotransmitter systems.
采用立体特异性[3H]二丙诺啡结合位点的放射自显影定位法，对脑干中阿片受体的分布进行了研究。显示受体定位非常密集或密集的区域包括臂旁核、上丘、腹侧中缝核、附属视觉系统的组成部分、缰核-脚间复合体的部分区域、顶盖前核和腹侧外侧膝状体、漏斗和内侧丘脑。在上髓质、中脑和间脑的广泛区域发现了中等密度的颗粒。从疼痛机制、一些受体与小直径轴突的关联、瞳孔反射、激素控制以及阿片类药物对神经递质系统的影响等方面讨论了这些发现的意义。
