Atweh S F, Kuhar M J
Brain Res. 1977 Oct 14;134(3):393-405. doi: 10.1016/0006-8993(77)90817-4.
Opiate receptor distribution, determined by the autoradiographic localization of stereospecific [3H]diprenorphine binding sites, was examined in the telencephalon. Areas showing very dense or dense localization of receptors included parts of the presubiculum and amygdala, patchy areas in the caudate-putamen and accumbens, the subfornical organ, the interstriatal nucleus of the striae terminalis and the anterior olfactory nucleus, pars externa. Lower densities were found in other parts of the hippocampal formation, the deeper part of the cerebral cortex, the entopeduncular nucleus, globus pallidus, nucleus triangularis septi and nucleus paratenialis. The significance of these findings is discussed in terms of the biochemical and physiological actions of opiates.
通过立体特异性[3H]二丙诺啡结合位点的放射自显影定位来确定阿片受体分布，该分布在端脑中进行了检查。显示受体非常密集或密集定位的区域包括前扣带回和杏仁核的部分区域、尾状核-壳核和伏隔核中的斑片状区域、穹窿下器官、终纹床核间纹状体核以及前嗅核外侧部。在海马结构的其他部分、大脑皮层较深部分、内囊核、苍白球、三角隔核和旁终核中发现较低密度。根据阿片类药物的生化和生理作用对这些发现的意义进行了讨论。
