阿片类物质[3H]二丙诺啡非传统结合位点在大鼠脑内的放射自显影分布。

Autoradiographic distribution in rat brain of a non-conventional binding site for the opiate [3H]diprenorphine.

作者信息

Morris B J, Herz A

出版信息

Brain Res. 1986 Oct 8;384(2):362-6. doi: 10.1016/0006-8993(86)91173-x.

Abstract

[3H]Diprenorphine, in the presence of saturating concentrations of mu, delta and kappa opiate receptor blocking agents, was found to label an additional binding site in rat brain, for which various opiates showed moderate affinity. Using light microscopic autoradiography, a unique, highly discrete distribution of binding sites was found, with a high density only in the globus pallidus, substantia nigra, interpeduncular nucleus, parabrachial nuclei and locus coeruleus. The identity of this binding site remains unclear.

摘要

在μ、δ和κ阿片受体阻断剂饱和浓度存在的情况下，发现[3H]二丙诺啡可标记大鼠脑中的另一个结合位点，各种阿片类药物对该位点显示出中等亲和力。使用光学显微镜放射自显影术，发现结合位点具有独特、高度离散的分布，仅在苍白球、黑质、脚间核、臂旁核和蓝斑中有高密度分布。该结合位点的身份仍不清楚。