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利用高速光学相干断层扫描技术对人视网膜进行三维成像。

Three-dimensional imaging of the human retina by high-speed optical coherence tomography.

作者信息

Hitzenberger Christoph, Trost Peter, Lo Pak-Wai, Zhou Qienyuan

出版信息

Opt Express. 2003 Oct 20;11(21):2753-61. doi: 10.1364/oe.11.002753.

Abstract

Conventional optical coherence tomography is based on A-scans, i.e., the fast scan direction is the z-direction. While this technique has been successfully demonstrated for two-dimensional cross sectional imaging of various tissues, it is rather slow if three-dimensional information is to be obtained. We report on a new technique that combines the transverse scanning approach of a confocal scanning laser ophthalmoscope with the depth sectioning capability of OCT. A stable high-frequency carrier is generated by use of an acousto optic modulator, and high frame rate is obtained by using a resonant scanning mirror for the priority scan (x-direction). Our prototype instrument records 64 transverse images consisting of 256x128 pixels in 1.2 seconds, thus providing the fastest retinal 3D OCT scanning system reported so far. We demonstrate the capabilities of our system by measuring and imaging the fovea and the optic nerve head region of healthy human volunteers in vivo.

摘要

传统光学相干断层扫描基于A扫描,即快速扫描方向为z方向。虽然该技术已成功用于各种组织的二维横截面成像,但如果要获取三维信息则相当缓慢。我们报告了一种新技术,该技术将共焦扫描激光检眼镜的横向扫描方法与光学相干断层扫描的深度切片能力相结合。通过使用声光调制器产生稳定的高频载波,并通过使用共振扫描镜进行优先扫描(x方向)来获得高帧率。我们的原型仪器在1.2秒内记录了由256x128像素组成的64幅横向图像,从而提供了迄今为止报道的最快的视网膜三维光学相干断层扫描系统。我们通过在体内测量和成像健康人类志愿者的中央凹和视神经乳头区域来展示我们系统的能力。

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