使用自适应光学扫描激光眼底镜/光学相干断层扫描对视网膜血管系统进行成像。
Imaging of retinal vasculature using adaptive optics SLO/OCT.
作者信息
Felberer Franz, Rechenmacher Matthias, Haindl Richard, Baumann Bernhard, Hitzenberger Christoph K, Pircher Michael
机构信息
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringerguertel 18-20, 1090 Vienna, Austria ; Imaging Cluster, Medical University of Vienna, Austria.
出版信息
Biomed Opt Express. 2015 Mar 23;6(4):1407-18. doi: 10.1364/BOE.6.001407. eCollection 2015 Apr 1.
Abstract
We use our previously developed adaptive optics (AO) scanning laser ophthalmoscope (SLO)/ optical coherence tomography (OCT) instrument to investigate its capability for imaging retinal vasculature. The system records SLO and OCT images simultaneously with a pixel to pixel correspondence which allows a direct comparison between those imaging modalities. Different field of views ranging from 0.8°x0.8° up to 4°x4° are supported by the instrument. In addition a dynamic focus scheme was developed for the AO-SLO/OCT system in order to maintain the high transverse resolution throughout imaging depth. The active axial eye tracking that is implemented in the OCT channel allows time resolved measurements of the retinal vasculature in the en-face imaging plane. Vessel walls and structures that we believe correspond to individual erythrocytes could be visualized with the system.
摘要
我们使用我们之前开发的自适应光学（AO）扫描激光检眼镜（SLO）/光学相干断层扫描（OCT）仪器来研究其对视网膜血管成像的能力。该系统以像素对像素的对应关系同时记录SLO和OCT图像，这使得可以在这些成像模式之间进行直接比较。该仪器支持从0.8°x0.8°到4°x4°的不同视场。此外，还为AO-SLO/OCT系统开发了一种动态聚焦方案，以便在整个成像深度保持高横向分辨率。在OCT通道中实现的主动轴向眼跟踪允许在正面成像平面中对视网膜血管进行时间分辨测量。我们认为与单个红细胞相对应的血管壁和结构可以用该系统可视化。
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