Haider A, Gooren L J G, Padungtod P, Saad F
Private urology praxis, Bremerhaven, Germany.
Exp Clin Endocrinol Diabetes. 2010 Mar;118(3):167-71. doi: 10.1055/s-0029-1202774. Epub 2009 May 26.
This is a study of a cohort of 117 men aged between 34-69 years, with plasma testosterone levels between 5.9-12.1 nmol/L (N>14.0 nmol/L) who were treated with administration of testosterone undecanoate for 1 year as the sole intervention. There was a remarkable improvement of body weight, BMI and waist size along with an improvement of lipid profiles. Liver fat is highly significantly and linearly correlated with all components of the metabolic syndrome. Hepatic inflammation secondary to liver steatosis is a potential contributor to the low-grade inflammation associated with the metabolic syndrome. Elevations of liver enzymes are associated with higher CRP concentrations. Levels of ALT (GPT) AST (GOT) and CRP had decreased significantly after one year of testosterone treatment. At baseline 74/117 met the criteria of the metabolic syndrome as defined by the NCEP and after one year of testosterone treatment this number had declined to 42/117.
这是一项针对117名年龄在34至69岁之间男性的队列研究，这些男性的血浆睾酮水平在5.9至12.1纳摩尔/升之间（正常>14.0纳摩尔/升），他们仅接受了十一酸睾酮治疗1年作为唯一干预措施。体重、体重指数和腰围有显著改善，同时血脂情况也得到改善。肝脏脂肪与代谢综合征的所有组分高度显著且呈线性相关。肝脂肪变性继发的肝脏炎症是与代谢综合征相关的低度炎症的潜在促成因素。肝酶升高与较高的C反应蛋白浓度相关。睾酮治疗一年后，谷丙转氨酶（GPT）、谷草转氨酶（GOT）和C反应蛋白水平显著下降。基线时，74/117符合美国国家胆固醇教育计划定义的代谢综合征标准，睾酮治疗一年后，这一数字降至42/117。
