糖尿病心脏中病理性肌纤维排列紊乱的缺失：这是一个悖论吗？

The absence of pathological myofibre disarray in the diabetic heart: is it a paradox?

作者信息

McLachlan Craig Steven, Lasker Shamima, Keramat Ali Shah M, Wang Lexin, Jelinek Herbert

机构信息

Department of Medical and Molecular Biosciences, University Technology Sydney, NSW, Australia.

出版信息

Acta Cardiol. 2009 Apr;64(2):267-8. doi: 10.2143/AC.64.2.2036148.

DOI:10.2143/AC.64.2.2036148

PMID:19476122

Abstract

Myofibre disarray in progressive hypertrophic cardiomyopathy (HCM) is a well established pathological cardiac tissue change and thereby represents a biomarker for that condition. On the other hand, in diabetic cardiomyopathy, myofibre disarray historically has been reported not to occur. This is surprising given that many of the pathological, remodelling and mechanical changes that present in the diabetic ventricle are also present in HCM, for example, myocardial stiffness, myocardial hypertrophy, apoptosis, cell slippage, extensive collagen expression and fibrosis. The question therefore begs is the absence of myocyte disarray in the diabetic heart a paradox or simply an oversight?

摘要

进行性肥厚型心肌病（HCM）中的肌纤维排列紊乱是一种公认的病理性心脏组织改变，因此是该疾病的生物标志物。另一方面，在糖尿病性心肌病中，历史上曾报道不存在肌纤维排列紊乱。鉴于糖尿病性心室中出现的许多病理、重塑和机械变化也存在于HCM中，例如心肌僵硬、心肌肥大、细胞凋亡、细胞滑移、广泛的胶原蛋白表达和纤维化，这一点令人惊讶。因此，问题在于糖尿病心脏中不存在心肌细胞排列紊乱是一种矛盾现象还是仅仅是一种疏忽？