8例克莱恩-莱文综合征患者的工作记忆：一项功能磁共振成像研究。
Working memory in 8 Kleine-Levin syndrome patients: an fMRI study.
作者信息
Engström Maria, Vigren Patrick, Karlsson Thomas, Landtblom Anne-Marie
机构信息
Center for Medical Image Sciences and Visualization, Linköping University, Linköping, Sweden.
出版信息
Sleep. 2009 May;32(5):681-8. doi: 10.1093/sleep/32.5.681.
Abstract
STUDY OBJECTIVES
The objectives of this study were to investigate possible neuropathology behind the Kleine-Levin Syndrome (KLS), a severe form of hypersomnia with onset during adolescence.
DESIGN
Functional magnetic resonance imaging (fMRI) applying a verbal working memory task was used in conjunction with a paper-and-pencil version of the task.
PARTICIPANTS
Eight patients with KLS and 12 healthy volunteers participated in the study.
RESULTS
The results revealed a pattern of increased thalamic activity and reduced frontal activity (involving the anterior cingulate and adjacent prefrontal cortex) while performing a reading span task.
DISCUSSION
This finding may explain the clinical symptoms observed in KLS, in that the thalamus is known to be involved in the control of sleep. Given the increasing access to fMRI, this investigation may aid clinicians in the diagnosis of patients suffering from severe forms of hypersomnia.
摘要
研究目的
本研究的目的是调查克莱因-莱文综合征（KLS）背后可能存在的神经病理学，这是一种在青春期发病的严重形式的嗜睡症。
设计
功能性磁共振成像（fMRI）结合纸笔版任务，应用言语工作记忆任务。
参与者
8名KLS患者和12名健康志愿者参与了该研究。
结果
结果显示，在执行阅读广度任务时，丘脑活动增加，额叶活动减少（涉及前扣带回和相邻的前额叶皮层）。
讨论
这一发现可能解释了KLS中观察到的临床症状，因为已知丘脑参与睡眠控制。鉴于越来越容易获得fMRI，这项研究可能有助于临床医生诊断患有严重形式嗜睡症的患者。
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3
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