Tobia Michael J, Woodruff-Pak Diana S
Department of Psychology, Temple University, Philadelphia, PA 19122, USA.
Behav Neurosci. 2009 Jun;123(3):665-76. doi: 10.1037/a0015662.
The authors examined 400 ms delay eyeblink classical conditioning in 20 participants with Fragile X syndrome ages 17 to 77 years, and 20 age-matched, healthy control participants. The participants in the Fragile X group demonstrated impaired learning and abnormal conditioned response timing. Adults with Fragile X (n=16) were also tested at two successive 12-month follow-up sessions to examine reacquisition and long-term retention. Participants in groups who were older and younger than 45 years demonstrated significant learning during each reacquisition session. Younger participants demonstrated greater retention of the conditioned stimulus/unconditioned stimulus association at each follow-up session than older participants. Fragile X impairs the acquisition and timing of conditioned eyeblink responses, but with repeated training adults with Fragile X syndrome show significant plasticity.
作者对20名年龄在17至77岁之间的脆性X综合征患者以及20名年龄匹配的健康对照者进行了400毫秒延迟眨眼经典条件反射测试。脆性X组的参与者表现出学习障碍和条件反应时间异常。还对16名患有脆性X的成年人进行了连续两次为期12个月的随访测试，以检查重新习得和长期记忆情况。年龄大于和小于45岁组的参与者在每次重新习得测试中均表现出显著的学习效果。在每次随访中，较年轻的参与者比较年长的参与者对条件刺激/非条件刺激关联的记忆保持得更好。脆性X会损害条件性眨眼反应的习得和时间控制，但通过反复训练，患有脆性X综合征的成年人会表现出显著的可塑性。
