硒补充剂可减少慢性四氯化碳处理后小鼠的肝纤维化。
Selenium supplementation decreases hepatic fibrosis in mice after chronic carbon tetrachloride administration.
机构信息
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205-2195, USA.
出版信息
Biol Trace Elem Res. 2010 Jan;133(1):83-97. doi: 10.1007/s12011-009-8414-x. Epub 2009 Jun 2.
Abstract
Oxidative stress stimulates fibrogenesis, and selenium (Se) has antioxidant properties. This study determined whether Se supplementation affects CCl(4)-induced liver injury and fibrosis. Mice were administered CCl(4) over 4 weeks, while controls received olive oil. Se was provided as sodium selenite in the drinking water. Se increased liver Se-dependent glutathione peroxidase activity and decreased liver malondialdehyde after CCl(4). Se decreased liver inflammation but not necrosis caused by CCl(4). Se increased hepatocyte apoptosis after CCl(4) and the pro-apoptotic BAX and Bcl Xs/l proteins. Stellate cell apoptosis occurred only after CCl(4) in Se-supplemented mice. Se decreased stellate cell number and fibrosis after CCl(4). Liver matrix metalloproteinase-9 increased after CCl(4) with Se supplementation. In conclusion, Se supplementation decreased hepatic fibrosis after CCl(4) in the setting of decreased inflammation but increased apoptosis. The principal mechanisms for the decreased fibrosis are a lower number of collagen-producing stellate cells and increased collagen degradation.
摘要
氧化应激刺激纤维化，而硒（Se）具有抗氧化特性。本研究旨在确定硒补充是否会影响 CCl(4)诱导的肝损伤和纤维化。小鼠在 4 周内接受 CCl(4)处理，而对照组则给予橄榄油。硒以亚硒酸钠的形式添加到饮用水中。硒可增加 CCl(4)后的肝硒依赖性谷胱甘肽过氧化物酶活性和降低肝丙二醛。硒可降低 CCl(4)引起的肝炎症但不引起坏死。硒可增加 CCl(4)后的肝细胞凋亡，并增加促凋亡的 BAX 和 Bcl Xs/l 蛋白。仅在补充硒的小鼠中，星状细胞在 CCl(4)后发生凋亡。硒可降低 CCl(4)后的星状细胞数量和纤维化。补充硒后，肝基质金属蛋白酶-9 增加。总之，在炎症减少但细胞凋亡增加的情况下，硒补充可减少 CCl(4)后的肝纤维化。纤维化减少的主要机制是胶原产生的星状细胞数量减少和胶原降解增加。
相似文献
1
Selenium supplementation decreases hepatic fibrosis in mice after chronic carbon tetrachloride administration.硒补充剂可减少慢性四氯化碳处理后小鼠的肝纤维化。
Biol Trace Elem Res. 2010 Jan;133(1):83-97. doi: 10.1007/s12011-009-8414-x. Epub 2009 Jun 2.
2
Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration.还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶缺乏增强慢性四氯化碳给药后的肝细胞损伤，但减轻纤维化。
Hepatology. 2009 Mar;49(3):911-9. doi: 10.1002/hep.22708.
3
Lack of inducible nitric oxide synthase leads to increased hepatic apoptosis and decreased fibrosis in mice after chronic carbon tetrachloride administration.缺乏诱导型一氧化氮合酶会导致小鼠在长期给予四氯化碳后肝脏细胞凋亡增加和纤维化减少。
Hepatology. 2008 Jun;47(6):2051-8. doi: 10.1002/hep.22278.
4
Transplantation of human amnion epithelial cells reduces hepatic fibrosis in immunocompetent CCl₄-treated mice.人羊膜上皮细胞移植可减轻免疫活性 CCl₄ 处理小鼠的肝纤维化。
Cell Transplant. 2010;19(9):1157-68. doi: 10.3727/096368910X504496. Epub 2010 May 4.
5
Amelioration of CCl-induced liver injury in rats by selenizing Astragalus polysaccharides: Role of proinflammatory cytokines, oxidative stress and hepatic stellate cells.硒化黄芪多糖对四氯化碳诱导的大鼠肝损伤的改善作用：促炎细胞因子、氧化应激和肝星状细胞的作用
Res Vet Sci. 2017 Oct;114:202-211. doi: 10.1016/j.rvsc.2017.05.002. Epub 2017 May 2.
6
Human amniotic epithelial cell transplantation induces markers of alternative macrophage activation and reduces established hepatic fibrosis.人羊膜上皮细胞移植诱导替代型巨噬细胞活化标志物的产生，并减轻已建立的肝纤维化。
PLoS One. 2012;7(6):e38631. doi: 10.1371/journal.pone.0038631. Epub 2012 Jun 14.
7
Inhibitory effect of olive oil on fibrosis induced by carbon tetrachloride in rat liver.橄榄油对四氯化碳诱导的大鼠肝纤维化的抑制作用。
Clin Nutr. 2008 Dec;27(6):900-7. doi: 10.1016/j.clnu.2008.08.004. Epub 2008 Sep 27.
8
Antifibrotic activity of anthocyanidin delphinidin in carbon tetrachloride-induced hepatotoxicity in mice.翠雀花素（一种矢车菊素）对四氯化碳诱导的小鼠肝毒性的抗纤维化作用。
Toxicology. 2010 Jun 4;272(1-3):1-10. doi: 10.1016/j.tox.2010.03.016. Epub 2010 Apr 3.
9
(Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione protects rats from carbon tetrachloride-induced liver injury and fibrogenesis.(Z)-5-(4-甲氧基苯亚甲基)噻唑烷-2,4-二酮可保护大鼠免受四氯化碳诱导的肝损伤和肝纤维化。
World J Gastroenterol. 2012 Feb 21;18(7):654-61. doi: 10.3748/wjg.v18.i7.654.
10
Hepatic fibrosis is enhanced and accompanied by robust oval cell activation after chronic carbon tetrachloride administration to Egr-1-deficient mice.慢性四氯化碳处理后，Egr-1 缺陷小鼠肝纤维化增强，并伴有活跃的肝卵圆细胞。
Am J Pathol. 2010 Jun;176(6):2743-52. doi: 10.2353/ajpath.2010.091186. Epub 2010 Apr 15.
引用本文的文献
1
The role and mechanism of selenium in the prevention and progression of hepatocellular carcinoma.硒在肝细胞癌预防和进展中的作用及机制。
Front Oncol. 2025 Mar 20;15:1557233. doi: 10.3389/fonc.2025.1557233. eCollection 2025.
2
Advances in Selenium and Related Compounds Inhibiting Multi-Organ Fibrosis.硒及相关化合物抑制多器官纤维化的研究进展
Drug Des Devel Ther. 2025 Jan 14;19:251-265. doi: 10.2147/DDDT.S488226. eCollection 2025.
3
Involvement of essential trace elements in the pathogenesis of hepatitis C virus‑related chronic liver disease and nonalcoholic steatohepatitis.必需微量元素在丙型肝炎病毒相关慢性肝病和非酒精性脂肪性肝炎发病机制中的作用。
Exp Ther Med. 2023 Nov 17;27(1):19. doi: 10.3892/etm.2023.12307. eCollection 2024 Jan.
4
Broad spectrum bioactivity of a novel β-glucan rich heteropolysaccharide, Pestalopine isolated from endophytic fungi Pestalotiopsis chamaeropsis CEL6.新型内生真菌层出镰刀菌 Pestalotiopsis chamaeropsis CEL6 中提取的富含β-葡聚糖杂多糖 Pestalopine 的广谱生物活性。
Arch Microbiol. 2023 Jul 12;205(8):284. doi: 10.1007/s00203-023-03620-x.
5
The Effect of Bioactive Aliment Compounds and Micronutrients on Non-Alcoholic Fatty Liver Disease.生物活性营养化合物和微量营养素对非酒精性脂肪性肝病的影响。
Antioxidants (Basel). 2023 Apr 10;12(4):903. doi: 10.3390/antiox12040903.
6
Inverse Association between Serum Selenium Level and Severity of Liver Fibrosis: A Cross-Sectional Study.血清硒水平与肝纤维化严重程度的负相关关系：一项横断面研究。
Nutrients. 2022 Sep 2;14(17):3625. doi: 10.3390/nu14173625.
7
The Role and Mechanisms of Selenium Supplementation on Fatty Liver-Associated Disorder.补充硒对脂肪肝相关病症的作用及机制
Antioxidants (Basel). 2022 May 8;11(5):922. doi: 10.3390/antiox11050922.
8
Dietary Selenium Alleviated Mouse Liver Oxidative Stress and NAFLD Induced by Obesity by Regulating the KEAP1/NRF2 Pathway.膳食硒通过调节KEAP1/NRF2通路减轻肥胖诱导的小鼠肝脏氧化应激和非酒精性脂肪性肝病
Antioxidants (Basel). 2022 Feb 10;11(2):349. doi: 10.3390/antiox11020349.
9
Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease.非酒精性脂肪性肝病中的硒转录组网络
Front Nutr. 2021 Nov 17;8:744825. doi: 10.3389/fnut.2021.744825. eCollection 2021.
10
Therapeutic Effects of an Inhibitor of Thioredoxin Reductase on Liver Fibrosis by Inhibiting the Transforming Growth Factor-β1/Smads Pathway.硫氧还蛋白还原酶抑制剂通过抑制转化生长因子-β1/Smads信号通路对肝纤维化的治疗作用
Front Mol Biosci. 2021 Sep 1;8:690170. doi: 10.3389/fmolb.2021.690170. eCollection 2021.
本文引用的文献
1
Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration.还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶缺乏增强慢性四氯化碳给药后的肝细胞损伤，但减轻纤维化。
Hepatology. 2009 Mar;49(3):911-9. doi: 10.1002/hep.22708.
2
Selenium attenuates pro-inflammatory gene expression in macrophages.硒可减弱巨噬细胞中促炎基因的表达。
Mol Nutr Food Res. 2008 Nov;52(11):1316-23. doi: 10.1002/mnfr.200700346.
3
Hydrogen peroxide causes cardiac dysfunction independent from its effects on matrix metalloproteinase-2 activation.过氧化氢导致心脏功能障碍，这与其对基质金属蛋白酶-2激活的影响无关。
Can J Physiol Pharmacol. 2007 Mar-Apr;85(3-4):341-8. doi: 10.1139/y07-003.
4
Apoptotic cellular events for selenium compounds involved in cancer prevention.参与癌症预防的硒化合物的细胞凋亡事件。
J Bioenerg Biomembr. 2007 Feb;39(1):91-8. doi: 10.1007/s10863-006-9065-7.
5
A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis.急性酒精性肝炎单独使用抗氧化剂治疗或联合皮质类固醇治疗的随机试验。
J Hepatol. 2007 Aug;47(2):277-83. doi: 10.1016/j.jhep.2007.03.027. Epub 2007 May 4.
6
Influences of reactive oxygen species and nitric oxide on hepatic fibrogenesis.活性氧和一氧化氮对肝纤维化形成的影响。
Liver Int. 2006 Dec;26(10):1248-57. doi: 10.1111/j.1478-3231.2006.01364.x.
7
The selenium metabolite methylselenol inhibits the migration and invasion potential of HT1080 tumor cells.硒代谢物甲基硒醇可抑制HT1080肿瘤细胞的迁移和侵袭能力。
J Nutr. 2006 Jun;136(6):1528-32. doi: 10.1093/jn/136.6.1528.
8
Protective effect of selenium-enriched Lactobacillus on CCl4-induced liver injury in mice and its possible mechanisms.富硒乳酸菌对四氯化碳诱导的小鼠肝损伤的保护作用及其可能机制。
World J Gastroenterol. 2005 Oct 7;11(37):5795-800. doi: 10.3748/wjg.v11.i37.5795.
9
Effects of dietary supplementation with vitamin E and selenium on rat hepatic stellate cell apoptosis.膳食补充维生素E和硒对大鼠肝星状细胞凋亡的影响。
World J Gastroenterol. 2005 Aug 28;11(32):4957-61. doi: 10.3748/wjg.v11.i32.4957.
10
Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis.基质金属蛋白酶-2和-14在实验性肝纤维化早期消退过程中持续表达，可能有助于纤维溶解。
Liver Int. 2004 Oct;24(5):492-501. doi: 10.1111/j.1478-3231.2004.0946.x.
Zotero 插件