Haensse Daniel, Szabo Peter, Brown Derek, Fauchère Jean-Claude, Niederer Peter, Bucher Hans-Ulrich, Wolf Martin
Opt Express. 2005 Jun 13;13(12):4525-38. doi: 10.1364/opex.13.004525.
We have designed a versatile, multi-channel near-infrared spectrophotometry (NIRS) instrument for the purpose of mapping neuronal activation in the neonatal and adult brain in response to motor, tactile, and visual stimulation. The optical linearity, stability, and high signal to noise ratio (>70 dB) of the instrument were demonstrated using an in vitro validation procedure. In vivo measurements on the adult forearm were also performed. Changes in oxygenation, induced by arterial occlusion of the forearm, were recorded and were shown to compare well with measurements acquired using a conventional NIRS instrument. To demonstrate the capabilities of the instrument, functional measurements in adults and neonates were performed. The instrument exhibited the capability to differentiate with a spatial resolution in the order of cm, local activation patterns associated with a finger tapping sequence.
我们设计了一种多功能、多通道近红外分光光度法（NIRS）仪器，用于绘制新生儿和成人脑部在运动、触觉和视觉刺激下的神经元激活图谱。通过体外验证程序证明了该仪器的光学线性、稳定性和高信噪比（>70 dB）。还对成人前臂进行了体内测量。记录了前臂动脉闭塞引起的氧合变化，并显示与使用传统NIRS仪器获得的测量结果具有良好的可比性。为了展示该仪器的功能，对成人和新生儿进行了功能测量。该仪器能够以厘米级的空间分辨率区分与手指敲击序列相关的局部激活模式。
