从巴西6型蜂胶中分离出的一种生物活性化合物的鉴定。
Identification of a bioactive compound isolated from Brazilian propolis type 6.
作者信息
Castro Myrella Lessio, do Nascimento Andréa Mendes, Ikegaki Masaharu, Costa-Neto Cláudio M, Alencar Severino M, Rosalen Pedro L
机构信息
Department of Physiological Sciences, Piracicaba Dental School, University of Campinas (UNICAMP), C.P. 52, 13414-903, Piracicaba, SP, Brazil.
出版信息
Bioorg Med Chem. 2009 Jul 15;17(14):5332-5. doi: 10.1016/j.bmc.2009.04.066. Epub 2009 May 3.
A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC(50)=0.1756microM), strong antimicrobial activity (MIC range-0.73-6.6microg/mL; MBC range-2.92-106microg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.
从巴西6型蜂胶的己烷馏分中分离出一种异戊烯化二苯甲酮——金丝桃素A。通过包括二维核磁共振在内的光谱分析确定了其结构。该化合物对人宫颈癌HeLa细胞表现出细胞毒性活性（半数抑制浓度IC(50)=0.1756微摩尔），对变形链球菌、远缘链球菌、口腔链球菌、金黄色葡萄球菌和内氏放线菌具有较强的抗菌活性（最低抑菌浓度范围为0.73 - 6.6微克/毫升；最低杀菌浓度范围为2.92 - 106微克/毫升），其细胞毒性和抗菌活性结果被认为良好。
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