Chen D, Li S
Hua Xi Yi Ke Da Xue Xue Bao. 1992 Jun;23(2):201-4.
Gastroendoscopic biopsy specimens from 366 patients were stained with HE, Warthin-Starrys or Giemsa and mucin histochemical methods. Positive rate of Helicobacter pylori (HP) was 73.8% in chronic gastritis. Positive rates of HP in gastric ulcer disease were 88.2%, 91.9%, and 11.1% at the near and distant mucosa of ulcer and in duodenitis, respectively. Positive rates of HP in duodenal ulcer disease were 81.5%, 24.6% and 7.2% at the pyloric-antral area and at the near and distant mucosa of duodenal ulcer, respectively. The number of HP in active inflammation was higher than that in inactive inflammation (P < 0.05). The HP almost lived in the neutral mucin. There was no statistical significant difference between near and distant mucosa of ulcer (P > 0.05). HP might play an important role in the pathogenesis of chronic gastritis, and it might aggravate the peptic ulcer disease.
对366例患者的胃内镜活检标本进行苏木精-伊红（HE）染色、沃辛-斯塔瑞（Warthin-Starry）染色或吉姆萨（Giemsa）染色以及黏液组织化学方法检测。慢性胃炎中幽门螺杆菌（HP）阳性率为73.8%。胃溃疡病中，溃疡近侧和远侧黏膜以及十二指肠炎症中HP阳性率分别为88.2%、91.9%和11.1%。十二指肠溃疡病中，幽门-胃窦区以及十二指肠溃疡近侧和远侧黏膜中HP阳性率分别为81.5%、24.6%和7.2%。活动性炎症中HP数量高于非活动性炎症（P<0.05）。HP大多存在于中性黏液中。溃疡近侧和远侧黏膜之间无统计学显著差异（P>0.05）。HP可能在慢性胃炎发病机制中起重要作用，且可能加重消化性溃疡病。
