CheA S对趋化磷酸酶CheZ进行定位的结构基础。
Structural basis for the localization of the chemotaxis phosphatase CheZ by CheAS.
作者信息
Hao Shufeng, Hamel Damon, Zhou Hongjun, Dahlquist Frederick W
机构信息
Department of Chemistry and Biochemistry, University of California-Santa Barbara, Santa Barbara, CA 93106, USA.
出版信息
J Bacteriol. 2009 Sep;191(18):5842-4. doi: 10.1128/JB.00323-09. Epub 2009 Jun 5.
Abstract
CheA-short interacts with CheZ to localize CheZ to cell poles. The fifth helical region (residues 112 to 133) from the phosphotransfer domain of CheA interacts with CheZ and becomes ordered and helical, although it lacks a stable fold in the CheA fragment comprising residues 98 to 150 alone. One CheA molecule binds to one CheZ dimer.
摘要
CheA短片段与CheZ相互作用，将CheZ定位到细胞极。CheA磷酸转移结构域的第五个螺旋区域（第112至133位氨基酸残基）与CheZ相互作用，并变得有序且呈螺旋状，尽管它在仅包含第98至150位氨基酸残基的CheA片段中缺乏稳定的折叠结构。一个CheA分子与一个CheZ二聚体结合。
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