Institute of Radiology, Department of Neuroradiology, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland.
Eur Radiol. 2009 Nov;19(11):2689-706. doi: 10.1007/s00330-009-1456-9. Epub 2009 Jun 6.
Several different techniques allow a functional assessment of neuronal activations by magnetic resonance imaging (fMRI). The by far most influential fMRI technique is based on a local T2*-sensitive hemodynamic response to neuronal activation, also known as the blood oxygenation level dependent or BOLD effect. Consequently, the term 'fMRI' is often used synonymously with BOLD imaging. Because interpretations of fMRI brain activation maps often appear intuitive and compelling, the reader might be tempted not to critically question the fundamental processes and assumptions. We review some essential processes and assumptions of BOLD fMRI and discuss related confounds and pitfalls in fMRI - from the underlying physiological effect, to data acquisition, data analysis and the interpretation of the results including clinical fMRI. A background framework is provided for the systematic and critical interpretation of fMRI results.
几种不同的技术允许通过磁共振成像（fMRI）对神经元激活进行功能评估。到目前为止，最有影响力的 fMRI 技术是基于对神经元激活的局部 T2*-敏感血液动力学反应，也称为血氧水平依赖或 BOLD 效应。因此，术语“fMRI”经常与 BOLD 成像同义使用。由于 fMRI 脑激活图的解释通常看起来直观且有说服力，读者可能会忍不住不去批判性地质疑基本过程和假设。我们回顾了 BOLD fMRI 的一些基本过程和假设，并讨论了 fMRI 中的相关混淆和陷阱-从潜在的生理效应，到数据采集、数据分析以及包括临床 fMRI 在内的结果解释。为系统和批判性地解释 fMRI 结果提供了背景框架。
