Lobmaier I V K, Vege A, Gaustad P, Rognum T O
University of Oslo, Oslo, Norway.
Eur J Clin Microbiol Infect Dis. 2009 Oct;28(10):1191-8. doi: 10.1007/s10096-009-0762-0. Epub 2009 Jun 6.
In cases of sudden unexpected death in infants and children (SUDI), microbiological investigation has been an important part of the autopsy protocol at the University of Oslo for the last 15 years. The purpose of this study was to compare the microbiological findings in samples taken at hospital admittance shortly after death and at autopsy. Blood cultures and cerebrospinal fluid (CSF) were collected both at the hospital and at autopsy; organ samples were additionally collected at autopsy. Hospital samples were collected at a median of 4.5 h (95% confidence interval [CI] 3.25-5) and autopsy samples at a median of 24.25 h (95% CI 22-25.5) after death. The proportion of positive cultures was stable over time; the post mortal time had no influence on bacterial growth. As long as the autopsy is performed within 48 h after death, prior microbiological examination is unnecessary. Blood culture, CSF and lung specimens are the best predictors in our study.
在婴幼儿及儿童猝死（SUDI）案例中，过去15年来微生物学调查一直是奥斯陆大学尸检方案的重要组成部分。本研究的目的是比较死亡后不久在医院入院时及尸检时所采集样本的微生物学检查结果。在医院及尸检时均采集血培养及脑脊液（CSF）样本；尸检时还额外采集器官样本。医院样本在死亡后中位时间4.5小时（95%置信区间[CI] 3.25 - 5）采集，尸检样本在死亡后中位时间24.25小时（95% CI 22 - 25.5）采集。阳性培养物的比例随时间保持稳定；死后时间对细菌生长无影响。只要在死亡后48小时内进行尸检，就无需事先进行微生物学检查。在我们的研究中，血培养、脑脊液及肺标本是最佳预测指标。
